1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-tetrahydrofuryl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-tetrahydrofuryl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid
• 英文别名: 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidine-5-carboxylic acid
• 化学式: C₁₀H₁₂N₂O₇
• 分子量: 272.21
• InChiKey: GAGYTXTVUMXAOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• METHOD FOR DETECTING TRIFLURIDINE- AND/OR TIPIRACIL-DERIVED ANALOGS
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3730935A1

  公开（公告）日：2020-10-28

  Provided is a method for detecting a trifluridine-related substance or a tipiracil-related substance or both, the method including the step of subjecting a sample containing trifluridine or a salt thereof and tipiracil or a salt thereof to high-performance liquid chromatography using a mobile phase composed of an organic phase and an aqueous phase.

  本发明提供了一种检测三氟尿苷相关物质或替吡嘧啶相关物质或两者的方法，该方法包括以下步骤：使用由有机相和水相组成的流动相，将含有三氟尿苷或其盐和替吡嘧啶或其盐的样品进行高效液相色谱分析。
• DETECTION METHOD FOR ANALOG DERIVED FROM TRIFLURIDINE
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3736568A1

  公开（公告）日：2020-11-11

  Provided is a method for detecting a trifluridine-related substance, the method including the step of subjecting a sample containing trifluridine or a salt thereof to high-performance liquid chromatography using a mobile phase composed of an organic phase and an aqueous phase, wherein the step of subjecting the sample to high-performance liquid chromatography includes steps 1 and 2 that satisfy the following requirements: Step 1: the percentage of the organic phase in the entire mobile phase is 1 to 14% by volume; and Step 2: after step 1, elution is performed by applying a gradient of increasing the percentage of the organic phase in the entire mobile phase.

  本发明提供了一种检测三氟尿苷相关物质的方法，该方法包括使用由有机相和水相组成的流动相将含有三氟尿苷或其盐的样品进行高效液相色谱分析的步骤，其中将样品进行高效液相色谱分析的步骤包括满足以下要求的步骤1和步骤2：步骤 1：有机相在整个流动相中的比例为 1%至 14%（体积比）； 步骤 2：在步骤 1 之后，通过增加有机相在整个流动相中的比例进行梯度洗脱。
• Method for detecting trifluridine-related substance by high-performance liquid chromatography
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US10816517B2

  公开（公告）日：2020-10-27

  The present invention provides a novel method that is capable of detecting a trifluridine-related substance from a sample containing trifluridine or a salt thereof by high-performance liquid chromatography comprising two steps that are performed under gradient conditions. More specifically, the method is for detecting a trifluridine-related substance, the method comprising the step of subjecting a sample containing trifluridine or a salt thereof to high-performance liquid chromatography using a mobile phase composed of an organic phase and an aqueous phase, wherein the step of high-performance liquid chromatography comprises steps 1 and 2 that satisfy the following requirements: Step 1: the percentage of the organic phase in the entire mobile phase is 1 to 14% by volume; and Step 2: after step 1, elution is performed by applying a gradient of increasing the percentage of the organic phase in the entire mobile phase.

  本发明提供了一种新型方法，能够通过高效液相色谱法从含有三氟尿苷或其盐的样品中检测三氟尿苷相关物质，该方法包括在梯度条件下进行的两个步骤。更具体地说，该方法用于检测三氟尿嘧啶相关物质，该方法包括以下步骤：使用由有机相和水相组成的流动相，对含有三氟尿嘧啶或其盐的样品进行高效液相色谱分析，其中高效液相色谱分析步骤包括满足以下要求的步骤 1 和步骤 2：步骤 1：有机相在整个流动相中的比例为 1%至 14%（体积比）； 步骤 2：在步骤 1 之后，通过增加有机相在整个流动相中的比例进行梯度洗脱。
• METHOD FOR DETECTING TRIFLURIDINE-RELATED SUBSTANCE BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20190212309A1

  公开（公告）日：2019-07-11

  The present invention provides a novel method that is capable of detecting a trifluridine-related substance from a sample containing trifluridine or a salt thereof by high-performance liquid chromatography comprising two steps that are performed under gradient conditions. More specifically, the method is for detecting a trifluridine-related substance, the method comprising the step of subjecting a sample containing trifluridine or a salt thereof to high-performance liquid chromatography using a mobile phase composed of an organic phase and an aqueous phase, wherein the step of high-performance liquid chromatography comprises steps 1 and 2 that satisfy the following requirements: Step 1: the percentage of the organic phase in the entire mobile phase is 1 to 14% by volume; and Step 2: after step 1, elution is performed by applying a gradient of increasing the percentage of the organic phase in the entire mobile phase.