4-(1-isopropyl-4-methyl-1,2,5,6-tetra-hydropyridin-2-yl)-5-methylbenzene-1,3-diol | 952516-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(1-isopropyl-4-methyl-1,2,5,6-tetra-hydropyridin-2-yl)-5-methylbenzene-1,3-diol
• 英文别名: 5-methyl-4-(4-methyl-1-propan-2-yl-3,6-dihydro-2H-pyridin-6-yl)benzene-1,3-diol
• CAS: 952516-02-8
• 化学式: C₁₆H₂₃NO₂
• 分子量: 261.364
• InChiKey: GHFGFXOHQSQRKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Abnormal Cannabidiols as agents for lowering intraocular pressure
  申请人：Chen June

  公开号：US20070249581A1

  公开（公告）日：2007-10-25

  The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula I wherein Y, Q, Z, R, R 1 and R 2 are as defined in the specification. The present invention further comprises pharmaceutical compositions, e.g. ophthalmic compositions, including said compound of formula I.

  本发明提供了一种治疗青光眼或眼压增高的方法，包括向需要该方法的人的眼睛施加足够治疗青光眼或眼压增高的化合物I的数量，其中Y、Q、Z、R、R1和R2如规范中所定义。本发明还包括药物组合物，例如眼科组合物，包括上述化合物I。
• Abnormal cannabidiols as agents for lowering intraocular pressure
  申请人：Chen June

  公开号：US20070249731A1

  公开（公告）日：2007-10-25

  The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula I wherein Y, Q, Z, R, R 1 and R 2 are as defined in the specification. The present invention further comprises pharmaceutical compositions, e.g. ophthalmic compositions, including said compound of formula I.

  本发明提供了一种治疗青光眼或眼压过高的方法，包括将式I的化合物应用于需要治疗青光眼或眼压过高的人的眼部，所述化合物的Y、Q、Z、R、R1和R2如规范中所定义。本发明还包括药物组合物，例如眼科组合物，包括上述式I的化合物。
• ABNORMAL CANNABIDIOLS AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE
  申请人：Chen June

  公开号：US20100010027A1

  公开（公告）日：2010-01-14

  The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula I wherein Y, Q, Z, R, R 1 and R 2 are as defined in the specification. The present invention further comprises pharmaceutical compositions, e.g. ophthalmic compositions, including said compound of formula I.

  本发明提供了一种治疗青光眼或眼压高的方法，包括向需要治疗青光眼或眼压高的人的眼睛中施加足够治疗青光眼或眼压高的化合物I的量，其中Y、Q、Z、R、R1和R2如规范中所定义。本发明还包括制药组合物，例如眼科组合物，包括上述的化合物I。
• US7618966B2
  申请人：——

  公开号：US7618966B2

  公开（公告）日：2009-11-17
• US7612101B2
  申请人：——

  公开号：US7612101B2

  公开（公告）日：2009-11-03