Benzonitrile, 3-((9-ethyl-2-((trans-4-hydroxycyclohexyl)amino)-9H-purin-6-yl)amino)- | 1229665-91-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Benzonitrile, 3-((9-ethyl-2-((trans-4-hydroxycyclohexyl)amino)-9H-purin-6-yl)amino)-
• 英文别名: 3-[[9-ethyl-2-[(4-hydroxycyclohexyl)amino]purin-6-yl]amino]benzonitrile
• CAS: 1229665-91-1
• 化学式: C₂₀H₂₃N₇O
• 分子量: 377.4
• InChiKey: YREVWYJUWQLUFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Purine derivatives for the treatment of cystic diseases
  申请人：GENZYME CORPORATION

  公开号：EP2617423A1

  公开（公告）日：2013-07-24

  Provided herein are methods of treatment of a cystic disease by administering a compound of Formula I. In certain embodiments, the compound for use in the methods provided herein is roscovitine or an analog thereof.

  本文提供了通过施用式 I 化合物治疗囊性疾病的方法。在某些实施例中，用于本文所提供方法的化合物是罗索维汀或其类似物。
• PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION
  申请人：Novartis AG

  公开号：EP0874846B1

  公开（公告）日：2003-04-02
• Purine Derivatives for Treatment of Cystic Diseases
  申请人：Bukanov Nikolay O.

  公开号：US20110046164A1

  公开（公告）日：2011-02-24

  Provided herein are methods of treatment of a cystic disease by administering a compound of Formula I. In certain embodiments, the compound for use in the methods provided herein is roscovitine or an analog thereof.
• PURINE DERIVATIVES FOR TREATMENT OF CYSTIC DISEASES
  申请人：Genzyme Corporation

  公开号：US20140249165A1

  公开（公告）日：2014-09-04

  Provided herein are methods of treatment of a cystic disease by administering a compound of Formula I. In certain embodiments, the compound for use in the methods provided herein is roscovitine or an analog thereof.
• US7091346B1
  申请人：——

  公开号：US7091346B1

  公开（公告）日：2006-08-15