(9H-Fluoren-9-yl)methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (9H-Fluoren-9-yl)methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
• 英文别名: 9H-fluoren-9-ylmethyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.4
• InChiKey: HJUXXCOVGMCKQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.39
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  49.77
• 氢给体数：
  1.0
• 氢受体数：
  3.0

文献信息

• SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR CONTROLLING GENE EXPRESSION
  申请人：Ohgi Tadaaki

  公开号：US20120010271A1

  公开（公告）日：2012-01-12

  Provided is a novel nucleic acid molecule that can inhibit the expression of a gene and can be produces easily and efficiently. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5′ side to the 3′ side: a 5′ side region (Xc); an inner region (Z); and a 3′ side region (Yc). The inner region (Z) is composed of an inner 5′ side region (X) and an inner 3′ side region (Y) that are linked to each other. The 5′ side region (Xc) is complementary to the inner 5′ side region (X). The 3′ side region (Yc) is complementary to the inner 3′ side region (Y). At least one of the inner region (Z), the 5′ side region (Xc), and the 3′ side region (Yc) includes the expression inhibitory sequence. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供了一种新型的核酸分子，可以抑制基因表达，并且可以轻松高效地制备。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。从5'端到3'端，该单链核酸分子包括：5'端区域（Xc），内部区域（Z）和3'端区域（Yc）。内部区域（Z）由内部5'端区域（X）和内部3'端区域（Y）组成，二者相连。5'端区域（Xc）与内部5'端区域（X）互补。3'端区域（Yc）与内部3'端区域（Y）互补。至少其中之一包括表达抑制序列。通过这种单链核酸分子，可以抑制目标基因的表达。
• SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING NITROGEN-CONTAINING ALICYCLIC SKELETON
  申请人：Ohgi Tadaaki

  公开号：US20120035246A1

  公开（公告）日：2012-02-09

  Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供了一种新型的核酸分子，可以轻松高效地制备，并能抑制基因表达。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子包括：一个区域（X）；一个连接区域（Lx）；和一个区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。至少其中一个区域（X）和（Xc）包含表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和一个哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。
• Single-Stranded Nucleic Acid Molecule Having Nitrogen-Containing Alicyclic Skeleton
  申请人：BONAC CORPORATION

  公开号：US20140171633A1

  公开（公告）日：2014-06-19

  Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供一种新型核酸分子，可以轻松高效地制备，并且可以抑制基因表达。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子包括：区域（X）；连接区域（Lx）；和区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。区域（X）和（Xc）中至少有一个包含表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。
• MULTICYCLIC COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Shao Liming

  公开号：US20130109677A1

  公开（公告）日：2013-05-02

  Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

  本文提供了多环化合物，其合成方法，包括该化合物的药物组合物，以及使用方法。本文提供的化合物对于治疗、预防和/或管理各种神经系统疾病非常有用，包括但不限于精神病和精神分裂症。
• Single-Stranded Nucleic Acid Molecule for Controlling Gene Expression
  申请人：BONAC CORPORATION

  公开号：US20150011605A1

  公开（公告）日：2015-01-08

  Provided is a novel nucleic acid molecule that is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5′ side to the 3′ side: a 5′ side region (Xc); an inner region (Z); and a 3′ side region (Yc). The inner region (Z) is composed of an inner 5′ side region (X) and an inner 3′ side region (Y) that are linked to each other. The 5′ side region (Xc) is complementary to the inner 5′ side region (X). The 3′ side region (Yc) is complementary to the inner 3′ side region (Y). At least one of the inner region (Z), the 5′ side region (Xc), and the 3′ side region (Yc) includes the expression inhibitory sequence.

  提供的是一种新型核酸分子，它是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子从5'端到3'端的序列包括：一个5'端区域（Xc）；一个内部区域（Z）；以及一个3'端区域（Yc）。内部区域（Z）由内部5'端区域（X）和内部3'端区域（Y）组成，它们彼此连接。5'端区域（Xc）与内部5'端区域（X）互补。3'端区域（Yc）与内部3'端区域（Y）互补。内部区域（Z）、5'端区域（Xc）和3'端区域（Yc）中至少有一个包含表达抑制序列。