(Z)-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acrylic acid | 113835-90-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噁庚英
• 英文名称: (Z)-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acrylic acid
• 英文别名: trans-3-[cis-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-yl]-acrylic acid；(E)-3-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]prop-2-enoic acid
• CAS: 113835-90-8
• 化学式: C₂₂H₂₃NO₃
• 分子量: 349.43
• InChiKey: NHJNJIIQOOIUFP-YLQCUUEWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative
  申请人：Smith D. Glenn

  公开号：US20050209312A1

  公开（公告）日：2005-09-22

  The present invention relates to topical formulations used for treating allergic and inflammatory diseases. More particularly, the present invention relates to formulations of carboxylic acid derivatives of doxepin preserved with gentle preservative formulations and their use for treating and/or preventing allergic or inflammatory disorders of the eye and nose.

  本发明涉及用于治疗过敏性和炎症性疾病的外用制剂。更具体地说，本发明涉及用温和的防腐剂配方保存的多塞平羧酸衍生物制剂及其用于治疗和/或预防眼鼻过敏性或炎症性疾病的用途。
• Tricyclic compounds
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0214779B1

  公开（公告）日：1990-04-11
• USE OF CONNECTIVE TISSUE MAST CELL STABILIZERS TO FACILITATE OCULAR SURFACE RE-EPITHELIZATION AND WOUND REPAIR
  申请人：Yanni John M.

  公开号：US20080139531A1

  公开（公告）日：2008-06-12

  Disclosed are methods of treating a wound in a subject that involve administering to the subject a pharmaceutically effective amount of a composition that includes one or more human connective tissue mast cell stabilizers, wherein administration of the composition results in treatment of the wound. In particular embodiments, the wound is an ophthalmic or dermal wound, such as a corneal epithelial defect, a conjunctival wound, or dermal abrasion. Administration, for example, may be by topical application of the composition to the ocular surface or skin. Exemplary mast cell stabilizers include olopatadine, variants of olopatadine, alcaftidine, derivatives of alcaftidine, dihydropyridines, and spleen tyrosine kinase inhibitors.
• US4871865A
  申请人：——

  公开号：US4871865A

  公开（公告）日：1989-10-03
• US4923892A
  申请人：——

  公开号：US4923892A

  公开（公告）日：1990-05-08