4,7,13,16,22-pentaoxa-1,10-diazabicyclo<8,8,7>pentacosane | 119017-39-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4,7,13,16,22-pentaoxa-1,10-diazabicyclo<8,8,7>pentacosane
• 英文别名: 4,7,13,16,22-Pentaoxa-1,10-diazabicyclo[8.8.7]pentacosane
• CAS: 119017-39-9
• 化学式: C₁₈H₃₆N₂O₅
• 分子量: 360.494
• InChiKey: PZLLSDKIBVWMHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  20,24-Dichloro-4,7,13,16,22-pentaoxa-1,10-diaza-bicyclo[8.8.7]pentacosane 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 4,7,13,16,22-pentaoxa-1,10-diazabicyclo<8,8,7>pentacosane
  参考文献：
  名称：

  大杂环。第42部分。二羟基隐链菌素的简便合成及其脱羟基作用

  摘要：

  据报道，通过二缩水甘油醚与二氮杂冠醚的反应，可以容易地合成羟基隐链烷烃。该反应产生可以通过色谱法分离的双环和三环穴状配体的混合物。随着二氮杂皇冠醚循环尺寸的减小和二缩水甘油醚中环氧基之间的氧化乙烯部分数量的增加，双环穴状配体的产率降低。用环氧基的分子内氢键促进反应中心的空间固定来解释该结果。已经通过氯化然后还原的方式进行了双环二羟基隐链糖的脱羟基化。

  DOI：

  10.1039/p19880002533

文献信息

• Macroheterocycles. Part 42. A facile synthesis of dihydroxy cryptands and their dehydroxylation
  作者：Nikolay G. Lukyanenko、Anatoly S. Reder

  DOI：10.1039/p19880002533

  日期：——

  A facile synthesis of hydroxy cryptands by the reaction of diglycidyl ethers with a diazacrown ether is reported. The reaction results in a mixture of bi- and tri-cyclic cryptands which can be separated by chromatography. The yield of bicyclic cryptands is lowered with a decrease in the diazacrown ether cycle size and an increase in the number of oxyethylene moieties between the epoxy groups in the

  据报道，通过二缩水甘油醚与二氮杂冠醚的反应，可以容易地合成羟基隐链烷烃。该反应产生可以通过色谱法分离的双环和三环穴状配体的混合物。随着二氮杂皇冠醚循环尺寸的减小和二缩水甘油醚中环氧基之间的氧化乙烯部分数量的增加，双环穴状配体的产率降低。用环氧基的分子内氢键促进反应中心的空间固定来解释该结果。已经通过氯化然后还原的方式进行了双环二羟基隐链糖的脱羟基化。
• Preparation and cation complexing properties of some macropolycyclic ligands
  作者：Krzysztof E. Krakowiak、Jerald S. Bradshaw、N. Kent Dalley、Chengyue Zhu、Guoliang Yi、Janet C. Curtis、Du Li、Reed M. Izatt

  DOI：10.1021/jo00037a038

  日期：1992.5

  Five new cryptands have been prepared by a 2:1 cyclocondensation of an alpha,omega-dihalide with an alpha,omega-diamine. In some cases, other products, such as bis(aza-12-crown-4) ligands and products of a 4:2 cyclocondensation, were isolated also. The structures of the cryptands and bis(aza-crown)s of the game molecular weight were established after careful analysis by C-13 NMR and X-ray spectroscopy and a few independent syntheses of the bis(aza-crown) ethers. A new TLC test has been developed to distinguish between the cryptands and the bis(aza-crown)s. Log K values for the interaction of two cryptands, each containing two propylene bridges in one arm, with various cations were determined. The results show a much weaker interaction of the cryptands containing two propylene bridges with various cations than that for the corresponding cryptands with only ethylene bridges. The most stable complexes of these new propylene-containing cryptands were those involving Ba2+ and Sr2+ ions. X-ray analyses of three cryptands, each of which has the [18]N2O4 macrocycle as part of its structure, show different organizations for the ring heteroatoms.
• LUKYANENKO, N. G.;REDER, A. S., ZH. ORGAN. XIMII, 25,(1989) N, S. 394-398
  作者：LUKYANENKO, N. G.、REDER, A. S.

  DOI：——

  日期：——
• LUKYANENKO, NIKOLAY G.;REDER, ANATOLY S., J. CHEM. SOC. PERKIN TRANS. PT I,(1988) N 9, C. 2533-2536
  作者：LUKYANENKO, NIKOLAY G.、REDER, ANATOLY S.

  DOI：——

  日期：——
• Luk'yanenko, N. G.; Reder, A. S., Journal of Organic Chemistry USSR (English Translation), 1989, vol. 25, # 2.2, p. 352 - 356
  作者：Luk'yanenko, N. G.、Reder, A. S.

  DOI：——

  日期：——