α,β-DL-Chalkose | 28072-68-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: α,β-DL-Chalkose
• 英文别名: D-Chalcose；4-Methoxy-6-methyloxane-2,3-diol
• CAS: 28072-68-6；28072-69-7；50663-99-5；99838-54-7；99838-56-9；99838-58-1
• 化学式: C₇H₁₄O₄
• 分子量: 162.186
• InChiKey: IPCYWPXJLMBEIB-UHFFFAOYSA-N

物化性质

• 沸点：
  256.7±40.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SYNERGISTIC ANTIBIOTIC COMBINATIONS AND DERIVATIVES
  申请人：Yonath Ada

  公开号：US20120316106A1

  公开（公告）日：2012-12-13

  Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions that include these improved analogs and synergistic combinations, along with methods for their production and use. The synergistic combinations target neighboring sites in the ribosome demonstrating the importance of the corresponding ribosomal sites for development of clinically-relevant synergistic antibiotics.