N1,N5-bis(6-amino-2-pyridinyl)pentanediamide | 229612-36-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N1,N5-bis(6-amino-2-pyridinyl)pentanediamide
• 英文别名: N,N'-bis(6-aminopyridin-2-yl)pentanediamide
• CAS: 229612-36-6
• 化学式: C₁₅H₁₈N₆O₂
• 分子量: 314.347
• InChiKey: HJDIPORTIQDUNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N1,N5-bis(6-amino-2-pyridinyl)pentanediamide 在 sodium tetrahydroborate 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 16.5h， 生成 N,N'-bis[6-[4-(2,5,8,11,14-pentaoxabicyclo[13.4.0]nonadeca-1(15),16,18-trien-17-ylsulfanyl)butanoylamino]pyridin-2-yl]pentanediamide
  参考文献：
  名称：

  Synthesis of a Novel Multi-Receptor Containing Hydrogen Bonding Sites and Ion Binding Sites

  摘要：

  A new linear ditopic receptor (1) which contains two 2,6-diaminopyridine moieties and two crown ether rings at the termini has been synthesized. The host (1) binds a thymine derivative and behaves as a ditopic receptor in a transport experiment.

  DOI：

  10.3987/com-98-s(h)79
• 作为产物：
  描述：

  2,6-二氨基吡啶 、 戊二酰基二氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.5h， 以50%的产率得到N1,N5-bis(6-amino-2-pyridinyl)pentanediamide
  参考文献：
  名称：

  Synthesis and Biological Activities of Some N-Acyl-2,6-diaminopyridines and Related Linker Mode Identical Twin Drugs

  摘要：

  In connection with our studies on biologically active compounds in the class of N-acyl-2,6-diaminopyridines, some molecular modifications were attempted. All of the synthesized compounds were evaluated for biological activity with herpes virus type 1 (HSV-1) by a plaque reduction assay. We observed that most of the synthesized derivatives showed no significant anti-HSV-1 activity, but we found that compounds 5 and 6 with a branched long alkyl chain showed high cytotoxicity to Vero cells.

  DOI：

  10.3987/com-10-12105

文献信息

• Synthesis and Biological Activities of Some N-Acyl-2,6-diaminopyridines and Related Linker Mode Identical Twin Drugs
  作者：Kunihiro Sumoto、Nobuko Mibu、Kazumi Yokomizo、Miyuki Saisho、Marumi Oishi、Hatsumi Aki、Takeshi Miyata

  DOI：10.3987/com-10-12105

  日期：——

  In connection with our studies on biologically active compounds in the class of N-acyl-2,6-diaminopyridines, some molecular modifications were attempted. All of the synthesized compounds were evaluated for biological activity with herpes virus type 1 (HSV-1) by a plaque reduction assay. We observed that most of the synthesized derivatives showed no significant anti-HSV-1 activity, but we found that compounds 5 and 6 with a branched long alkyl chain showed high cytotoxicity to Vero cells.
• Synthesis of a Novel Multi-Receptor Containing Hydrogen Bonding Sites and Ion Binding Sites
  作者：Tatsuya Nabeshima、Takeshi Hanami

  DOI：10.3987/com-98-s(h)79

  日期：——

  A new linear ditopic receptor (1) which contains two 2,6-diaminopyridine moieties and two crown ether rings at the termini has been synthesized. The host (1) binds a thymine derivative and behaves as a ditopic receptor in a transport experiment.