2-cyclopentyl-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-cyclopentyl-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}acetic acid
• 英文别名: 2-cyclopentyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)acetic acid
• 化学式: C₂₂H₂₃NO₄
• 分子量: 365.4
• InChiKey: JGWHUIQSEKGLAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
  申请人：Pfizer Inc.

  公开号：US10039778B2

  公开（公告）日：2018-08-07

  Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.

  本文描述了式(A)化合物及其在治疗由药物组合物介导的疾病、病症和/或失调方面的用途，以及其作为淀粉糖蛋白受体（ASGPR）靶向制剂的用途。
• Tissue-specific genome engineering using CRISPR-Cas9
  申请人：Pfizer Inc.

  公开号：US10851367B2

  公开（公告）日：2020-12-01

  The present application provides compounds, compositions, uses thereof for the treatment of diseases, conditions and/or disorders, and uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.

  本申请提供了用于治疗疾病、病症和/或失调的化合物、组合物及其用途，以及其作为淀粉样糖蛋白受体（ASGPR）靶向药物的用途。
• TISSUE-SPECIFIC GENOME ENGINEERING USING CRISPR-CAS9
  申请人：Pfizer Inc.

  公开号：US20170137801A1

  公开（公告）日：2017-05-18

  The present application provides compounds, compositions, uses thereof for the treatment of diseases, conditions and/or disorders, and uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.
• SUBSTITUTED-6,8-DIOXABICYCLO[3.2.1]OCTANE-2,3-DIOL COMPOUNDS AS TARGETING AGENTS OF ASGPR
  申请人：Pfizer Inc.

  公开号：US20170165284A1

  公开（公告）日：2017-06-15

  Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting agents.
• US9617293B2
  申请人：——

  公开号：US9617293B2

  公开（公告）日：2017-04-11