5,6,7,-三氟-3,4-二氢-1H-2-萘酮 | 313947-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 5,6,7,-三氟-3,4-二氢-1H-2-萘酮
• 英文名称: 5,6,7-trifluoro-3,4-dihydronaphthalen-2(1H)-one
• 英文别名: 5,6,7-trifluoro-3,4-dihydro-2(1H)-naphthalenone；5,6,7-trifluoro-3,4-dihydro-1H-naphthalen-2-one
• CAS: 313947-31-8
• 化学式: C₁₀H₇F₃O
• 分子量: 200.16
• InChiKey: PEYRRKMBGLNDCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,6,7,-三氟-3,4-二氢-1H-2-萘酮 在 对甲苯磺酸 作用下， 生成 2-(4-propylphenyl)-5,6,7-trifluoro-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Design, Synthesis and Physical Properties of New Liquid Crystal Materials Having a Fluoro-Substituted Tetrahydronaphthalene Structure for Active Matrix LCD

  摘要：

  Liquid crystal materials having a fluoro-substituted tetralhydro-naphthalene structure were designed for active matrix LCD. 6-Aryl-5-fluoro-1,2,3,4-tetrahydronaphthalenes and 5,6-difluro-1,2,3,4-tetrahydronaphthalenes were prepared by regioselective fluorination and hydrogenation of 2-naphthols. 6-Aryl-5,7-difluoro-1,2,3,4-tetrahydronaphthalenes were synthesized from 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-one. The liquid crystal mixture containing these compounds with very good co-solubility exhibits a wide nematic temperature range with low melting point and very large value of dielectric anisotropy. From these results these compounds are useful for design. of new liquid crystal mixtures for TFT-displays.

  DOI：

  10.1080/15421400490434973
• 作为产物：
  描述：

  3,4,5-trifluorophenylacetic acid chloride 、 乙烯 在 aluminum (III) chloride 作用下， 生成 5,6,7,-三氟-3,4-二氢-1H-2-萘酮
  参考文献：
  名称：

  COMPOUND HAVING TETRAHYDRONAPHTHALENE SKELETON AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME

  摘要：

  公开号：

  EP1191008B1

文献信息

• Novel Cercosporamide Derivative
  申请人：Furukawa Akihiro

  公开号：US20090036492A1

  公开（公告）日：2009-02-05

  The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a therapeutic and/or prophylactic agent for diabetes. A cercosporamide derivative having the general formula (I): [wherein X represents an oxygen atom or the like, R 1 represents a hydrogen atom or a C 1 -C 6 alkyl group, R 2 represents a hydrogen atom, a C 1 -C 6 alkyl group or a C 1 -C 6 halogenated alkyl group, R 3 represents a hydrogen atom or a C 1 -C 6 alkyl group, R 4 represents a C 6 -C 10 aryl group which may be substituted with one to five group(s) independently selected from Substituent Group a, or the like, n represents 1, 2 or 3, and Substituent Group a represents a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, a C 2 -C 6 alkenyl group, a C 2 -C 6 alkynyl group, a C 1 -C 6 alkoxy group, a C 1 -C 6 halogenated alkoxy group, a C 2 -C 6 alkenyloxy group, a C 2 -C 6 alkynyloxy group and the like], a pharmacologically acceptable salt thereof or an ester thereof.

  本发明涉及一种新型的环孢霉素衍生物，其具有优异的降血糖作用，可作为糖尿病治疗和/或预防制剂使用的药物学上可接受的盐或酯。 具有以下通式（I）的环孢霉素衍生物： [其中，X代表氧原子或类似物，R1代表氢原子或C1-C6烷基，R2代表氢原子、C1-C6烷基或C1-C6卤代烷基，R3代表氢原子或C1-C6烷基，R4代表C6-C10芳基，该芳基可被一个到五个独立选择的取代基a取代，n代表1、2或3，取代基a代表卤原子、C1-C6烷基、C1-C6卤代烷基、C2-C6烯基、C2-C6炔基、C1-C6烷氧基、C1-C6卤代烷氧基、C2-C6烯氧基、C2-C6炔氧基等]，其药学上可接受的盐或酯。
• NOVEL CERCOSPORAMIDE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP1914229B1

  公开（公告）日：2010-06-16
• US6746728B1
  申请人：——

  公开号：US6746728B1

  公开（公告）日：2004-06-08
• COMPOUND HAVING TETRAHYDRONAPHTHALENE SKELETON AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP1191008B1

  公开（公告）日：2005-02-09
• Design, Synthesis and Physical Properties of New Liquid Crystal Materials Having a Fluoro-Substituted Tetrahydronaphthalene Structure for Active Matrix LCD
  作者：Tetsuo Kusumoto、Yoshitaka Saito、Yutaka Nagashima、Makoto Negishi、Sadao Takehara、Yoshinori Iwashita、Kiyofumi Takeuchi、Haruyoshi Takatsu、Corneria Pithart、Rainer Frings、Artur Lachowicz、Gerwald Grahe

  DOI：10.1080/15421400490434973

  日期：2004.1

  Liquid crystal materials having a fluoro-substituted tetralhydro-naphthalene structure were designed for active matrix LCD. 6-Aryl-5-fluoro-1,2,3,4-tetrahydronaphthalenes and 5,6-difluro-1,2,3,4-tetrahydronaphthalenes were prepared by regioselective fluorination and hydrogenation of 2-naphthols. 6-Aryl-5,7-difluoro-1,2,3,4-tetrahydronaphthalenes were synthesized from 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-one. The liquid crystal mixture containing these compounds with very good co-solubility exhibits a wide nematic temperature range with low melting point and very large value of dielectric anisotropy. From these results these compounds are useful for design. of new liquid crystal mixtures for TFT-displays.