6-amino-9-(2-(p-tolyloxy)ethyl)-9H-purine-8-thiol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-amino-9-(2-(p-tolyloxy)ethyl)-9H-purine-8-thiol
• 英文别名: 6-Amino-9-(2-p-tolyloxy-ethyl)-9H-purine-8-thiol；6-amino-9-[2-(4-methylphenoxy)ethyl]-7H-purine-8-thione
• 化学式: C₁₄H₁₅N₅OS
• mdl: MFCD02908130
• 分子量: 301.372
• InChiKey: KKSYXUAEBWBHOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compounds for immunopotentiation
  申请人：Valiante Nicholas

  公开号：US20100226931A1

  公开（公告）日：2010-09-09

  Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed. In a preferred embodiment benzopyrimidine derivatives such as ZD-6474, MLN-518, lapatinib, gefitinib or erlotinib are used.

  本发明公开了刺激免疫反应和治疗对3,4-二（1H-吲哚-3-基）-1H-吡咯-2,5-二酮，链霉菌素类似物，衍生的吡啶并嗪，香豆素-4-酮，吲哚酮，喹唑啉，核苷类似物和其他小分子具有响应性的患者。在一种优选实施方式中，使用苯并嘧啶衍生物，例如ZD-6474，MLN-518，拉帕替尼，吉非替尼或厄洛替尼。
• PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN
  申请人：Forever Cheer International Limited

  公开号：EP3403674A1

  公开（公告）日：2018-11-21

  The present invention discloses a novel use of a pharmaceutical composition in the preparation of a medicament in the treatment of opioid-induced tolerance and addiction, in particular to the use of ACl inhibitor NB001 and AC1 &8 mixed inhibitors NB010 and NB011 in the preparation of a medicament in the treatment of opioid-induced tolerance and addiction.

  本发明公开了一种药物组合物在制备治疗阿片类药物引起的耐受性和成瘾的药物中的新用途，特别是ACl抑制剂NB001和AC1 & 8混合抑制剂NB010和NB011在制备治疗阿片类药物引起的耐受性和成瘾的药物中的用途。
• METHOD FOR TREATING NEURONAL AND NON-NEURONAL PAIN
  申请人：Zhuo, Min

  公开号：EP1948182B1

  公开（公告）日：2012-12-12
• Method for Treating Neuronal and Non-Neuronal Pain
  申请人：Zhuo Min

  公开号：US20090233922A1

  公开（公告）日：2009-09-17

  A method for the combined treatment of neuronal and non-neuronal pain in mammals is provided comprising administration of adenylyl cyclase 1 inhibitors having the following general formula (1): (1) wherein: G, H, J and M are each N, or H and J are each C, and G and M are each N, S or O, or H, J and M are each C and G is N, S or O.
• METHODS OF TREATING ANXIETY, ITCHING AND PSYCHIATRIC DISORDERS
  申请人：Zhuo Min

  公开号：US20110098295A1

  公开（公告）日：2011-04-28

  A method of treating an undesirable AC8-related condition in a mammal is provided comprising the step of inhibiting AC8 in the mammal