1-(butan-2-yl)-4,6-dihydroxy-5-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)pyrimidin-2(1H)-one

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 1-(butan-2-yl)-4,6-dihydroxy-5-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)pyrimidin-2(1H)-one
• 英文别名: 1-butan-2-yl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4-dione
• 化学式: C₁₉H₂₂N₄O₃
• 分子量: 354.4
• InChiKey: KKMQIOYPICZRAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  97.5
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• E3 LIGASE INHIBITORS
  申请人：Stockwell Brent R.

  公开号：US20120135089A1

  公开（公告）日：2012-05-31

  The present invention provides, e.g., compounds having the structure of formula (I): The present invention also provides pharmaceutical compositions that include such compounds, and methods for modulating murine double minute 2 protein (Mdm2) E3 ligase activity, particularly the Mdm2-MdmX hetero-complex E3 ligase activity, using such compounds.