3-methyl-1-(2-methylpropyl)-7H-purine-2,6-dione | 76054-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-methyl-1-(2-methylpropyl)-7H-purine-2,6-dione
• CAS: 76054-34-7
• 化学式: C₁₀H₁₄N₄O₂
• 分子量: 222.24
• InChiKey: DZAZIOFIVCEFLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-溴-1-己炔 、 3-methyl-1-(2-methylpropyl)-7H-purine-2,6-dione 、 sodium hydroxide 生成 7-hex-5-ynyl-3-methyl-1-(2-methylpropyl)purine-2,6-dione
  参考文献：
  名称：

  MIYAGAKI, MITIXIRO;SAKAI, SINITIRO;XORI, MIKIO;KOGO, SINSIRO;KAVAXARA, MO+

  摘要：

  DOI：

文献信息

• METHODS OF MANAGING BLOOD SUGAR LEVELS AND COMPOSITIONS RELATED THERETO
  申请人：Ye Keqiang

  公开号：US20130158082A1

  公开（公告）日：2013-06-20

  The disclosure relates to methods of managing blood sugar levels and compositions related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diabetes, insulin resistance, or hyperglycemia comprising administering to a subject diagnosed with, at risk of or exhibiting symptoms of diabetes, insulin resistance, or hyperglycemia a pharmaceutical composition comprising a compound comprising formula I.

  本公开涉及管理血糖水平的方法及相关组合物。在某些实施例中，本公开涉及治疗或预防糖尿病、胰岛素抵抗或高血糖的方法，包括向被诊断为、处于风险中或表现出糖尿病、胰岛素抵抗或高血糖症状的受试者施用含有式I化合物的制药组合物。
• Biological factors and neural stem cells
  申请人：NEUROSPHERES HOLDINGS LTD.

  公开号：EP1298202A2

  公开（公告）日：2003-04-02

  Methods are described for increasing the number of neural stem cells that differentiate into astrocytes, oligodendrocytes, or neurons. The methods comprise proliferating isolated neural stem cells in a culture medium having a first growth factor to produce precursor cells. The precursor cells are then differentiated into astrocytes, oligodendrocytes, or neurons in a second culture medium, EGF-free and containing a differentiation-inducing growth factor.

  本文描述了增加分化为星形胶质细胞、少突胶质细胞或神经元的神经干细胞数量的方法。这些方法包括在含有第一生长因子的培养基中增殖分离的神经干细胞，以产生前体细胞。然后，前体细胞在不含 EGF 并含有分化诱导生长因子的第二种培养基中分化成星形胶质细胞、少突胶质细胞或神经元。
• SALT-INDUCIBLE KINASES 2 AND USE THEREOF
  申请人：Proteinexpress Co., Ltd.

  公开号：EP1544295A1

  公开（公告）日：2005-06-22

  The polypeptide of the present invention has the amino acid sequence represented by SEQ ID NO: 2, 4, 6, 8, 10, or 12. The polypeptide of the present invention is useful as an agent for preventing or improving a disease with which the metabolic disorder of fat cells or the like is associated.

  本发明的多肽具有 SEQ ID NO：2、4、6、8、10 或 12 所代表的氨基酸序列。本发明的多肽可用作预防或改善脂肪细胞代谢紊乱或类似疾病的药物。
• Biomanufacturing suite and methods for large-scale production of cells, viruses, and biomolecules
  申请人：BIOVEST INTERNATIONAL, INC.

  公开号：US10662401B2

  公开（公告）日：2020-05-26

  The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.

  本发明提供了一种用于大规模生产细胞和/或细胞衍生产品（如抗体或病毒）的生产模块；一种由多个功能连接的本发明生产模块组成的生产套件；以及一种使用本发明生产模块和/或生产套件大规模生产细胞和/或细胞衍生产品的方法。
• Methods of screening biological agents
  申请人：——

  公开号：US20030082515A1

  公开（公告）日：2003-05-01

  The invention discloses methods of proliferation and differentiation of multipotent neural stem cells. Also provided are methods of making cDNA libraries and methods of screening biological agents which affect proliferation differentiation survival phenotype or function of CNS cells.

  本发明公开了多能神经干细胞的增殖和分化方法。本发明还提供了制作 cDNA 文库的方法和筛选影响中枢神经系统细胞增殖分化存活表型或功能的生物制剂的方法。