isoindolo[1,2-b]quinazoline-10,12-dione | 19910-55-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: isoindolo[1,2-b]quinazoline-10,12-dione
• CAS: 19910-55-5
• 化学式: C₁₅H₈N₂O₂
• 分子量: 248.241
• InChiKey: KYRHFTTYGXVIOH-UHFFFAOYSA-N

物化性质

• 熔点：
  217-219 °C(Solv: 1,4-dioxane (123-91-1))
• 沸点：
  469.3±28.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-氧代-1H-喹唑啉-2-基)苯甲酸 在 sodium acetate 作用下， 以 乙酸酐 为溶剂， 生成 isoindolo[1,2-b]quinazoline-10,12-dione
  参考文献：
  名称：

  Reaction of anthranilic acid amides with cyclic anhydrides

  摘要：

  Anthranilic acid amide reacts with cyclic anhydrides to give the corresponding N-acyl derivatives at the amino group, while analogous reactions of o-aminobenzohydroxamic acid lead to fori-nation of 3-hydroxy-quinazolin-4-ones under mild conditions. N-Acyl derivatives of anthranilic acid amide undergo intramolecular cyclization to imides on microwave irradiation or on melting, and their treatment with acetic anhydride in the presence of sodium acetate on heating yields quinazolin-4-ones.

  DOI：

  10.1134/s1070428006030079

文献信息

• A Novel Domino Synthesis of Quinazolinediones by Palladium-Catalyzed Double Carbonylation
  作者：Haoquan Li、Wanfang Li、Anke Spannenberg、Wolfgang Baumann、Helfried Neumann、Matthias Beller、Xiao-Feng Wu

  DOI：10.1002/chem.201403417

  日期：2014.7.7

  Combining commercially available bromoanilines and bromobenzonitriles in a novel double carbonylation process allows for a straightforward synthesis of isoindolo[1,2‐b]quinazoline‐10,12‐diones. At least five different CC and/or CN bonds are selectively formed in this 3‐component reaction, which likely proceeds through sequential carbonylation–cyclization–isomerisation–carbonylation steps. Notably

  在新颖的双羰基化工艺中，将市售的溴苯胺和溴苯甲腈结合使用，可以直接合成异吲哚并[1,2-b]喹唑啉-10,12-二酮。在此三组分反应中，至少有五个不同的CC和/或CN键选择性地形成，这很可能会通过依次进行的羰基化-环化-异构化-羰基化步骤进行。值得注意的是，在这种高效的钯催化过程中插入了两个CO分子。
• Flash Vacuum Pyrolysis of Some N-Benzylbenzotriazoles and N-Benzylbenzisoxazolones
  作者：Jabbar Khalafy、Rolf H Prager

  DOI：10.1071/c98065

  日期：——

  The flash vacuum pyrolysis products of 2-(benzotriazol-1-ylmethyl)benzonitrile, methyl 2-(benzotriazol-1-ylmethyl)benzoate and the corresponding benzisoxazolones have been characterized. The benzotriazoles lose nitrogen to give diradicals which undergo intramolecular hydrogen-atom transfer or cyclization, while the benzisoxazolones rearrange initially to the corresponding benzaldehyde N-(2-carboxyphenyl)imines which undergo subsequent intramolecular addition reactions.

  以下物质的闪速真空热解产物 2-(苯并三唑-1-基甲基)苯甲腈、2-(苯并三唑-1-基甲基)苯甲酸甲酯 2-(苯并三唑-1-基甲基)苯甲酸酯和相应的苯并异噁唑酮的闪速真空热解产物 的特征。苯并三唑失去氮元素后会产生二元杂环 进行分子内氢原子转移或环化，而苯并异噁唑酮则 而苯并异噁唑酮最初会重排为相应的苯甲醛 N-（2-羧基苯基）亚胺，随后发生分子内加成反应。 分子内加成反应。
• Liquid Crystal Display Operating in a Vertically Aligned Mode
  申请人：Palto Serguei Petrovich

  公开号：US20100118241A1

  公开（公告）日：2010-05-13

  The present invention relates generally to the field of liquid crystal display devices and more particularly to a liquid crystal display device operating in vertically aligned mode (VA-mode) in which liquid crystal molecules having a negative dielectric anisotropy are aligned generally perpendicularly to a panel surface of the liquid crystal display. A liquid crystal display according to the invention comprises a liquid crystal cell ( 6 ) of a vertical alignment mode, at least one polarizer ( 2, 10 ) arranged on each side of the liquid crystal cell, and at least one compensating structure ( 3, 7 ) disposed between the liquid crystal cell and at least one of the polarizers. The polarizers have transmission axes ( 11, 18 ) which are perpendicular to each other.

  本发明涉及液晶显示器件领域，更具体地涉及一种在垂直对准模式（VA模式）下运行的液晶显示器件，其中具有负介电各向异性的液晶分子通常垂直于液晶显示器件的面板表面。本发明的液晶显示器包括垂直对准模式的液晶电池（6），至少一个极化器（2、10）分别设置在液晶电池的两侧，以及至少一个补偿结构（3、7）设置在液晶电池和至少一个极化器之间。极化器具有相互垂直的透过轴（11、18）。
• Heterocycles by intramolecular aza-Wittig reactions of iminophosphoranes obtained from 2-azidobenzoyl- and 2-azidobenzylidene derivatives
  作者：Abdul-Bassett N. Luheshi、Salem M. Salem、Robert K. Smalley、Peter D. Kennewell、Robert Westwood

  DOI：10.1016/s0040-4039(00)97117-x

  日期：1990.1
• LUHESHI, ABDUL-BASSETT N.;SALEM, SALEM M.;SMALLEY, ROBERT K.;KENNEWELL, P+, TETRAHEDRON LETT., 31,(1990) N5, C. 6561-6564
  作者：LUHESHI, ABDUL-BASSETT N.、SALEM, SALEM M.、SMALLEY, ROBERT K.、KENNEWELL, P+

  DOI：——

  日期：——