2-(4-benzyloxybenzylidene)-3,4-dihydronaphthalen-1-(2H)-one | 154226-83-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-(4-benzyloxybenzylidene)-3,4-dihydronaphthalen-1-(2H)-one
• 英文别名: 2-(4-(Benzyloxy)benzylidene)-3,4-dihydronaphthalen-1(2H)-one；2-[(4-phenylmethoxyphenyl)methylidene]-3,4-dihydronaphthalen-1-one
• CAS: 154226-83-2
• 化学式: C₂₄H₂₀O₂
• 分子量: 340.422
• InChiKey: NPHCHRKNCBGLCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-苄氧基苯甲醛 、 3,4-二氢-1(2H)-萘酮 在 silica chloride 作用下， 反应 10.0h， 以85%的产率得到2-(4-benzyloxybenzylidene)-3,4-dihydronaphthalen-1-(2H)-one
  参考文献：
  名称：

  Highly Selective Claisen–Schmidt Condensation Catalyzed by Silica Chloride Under Solvent-Free Reaction Conditions

  摘要：

  Silica chloride serves as a useful catalyst in the cross-aldol condensation, leading to the synthesis of a wide variety of bisarylidene cycloalkanones and chalcones. The catalyst showed high selectivity; self-condensation of ketones was not observed.

  DOI：

  10.1080/00397910903340637

文献信息

• Highly Selective Claisen–Schmidt Condensation Catalyzed by Silica Chloride Under Solvent-Free Reaction Conditions
  作者：Hassan Hazarkhani、Pradeep Kumar、Kadam Sachin Kondiram、Ikhlas M. Shafi Gadwal

  DOI：10.1080/00397910903340637

  日期：2010.8.31

  Silica chloride serves as a useful catalyst in the cross-aldol condensation, leading to the synthesis of a wide variety of bisarylidene cycloalkanones and chalcones. The catalyst showed high selectivity; self-condensation of ketones was not observed.