2(1H)-Quinazolinone, 6-chloro-3,4-diethyl-3,4-dihydro-4-phenyl- | 681431-41-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2(1H)-Quinazolinone, 6-chloro-3,4-diethyl-3,4-dihydro-4-phenyl-
• 英文别名: 6-chloro-3,4-diethyl-4-phenyl-1H-quinazolin-2-one
• CAS: 681431-41-4
• 化学式: C₁₈H₁₉ClN₂O
• 分子量: 314.8
• InChiKey: PDTBMXMSRREKOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• ENHANCEMENT OF SLEEP WITH T-TYPE CALCIUM CHANNEL ANTAGONISTS
  申请人：Merck & Co., Inc.

  公开号：EP1553946A2

  公开（公告）日：2005-07-20
• EP1553946A4
  申请人：——

  公开号：EP1553946A4

  公开（公告）日：2008-07-16
• Enhancement of sleep with t-type calcium channel antagonists
  申请人：Renger J. John

  公开号：US20060003985A1

  公开（公告）日：2006-01-05

  A T-type calcium channel antagonist is useful, alone or in combination with other agents, for inducing sleep and enhancing and improving the quality of sleep, in particular by increasing sleep efficiency and augmenting sleep maintenance.
• USES, COMPOSITIONS AND METHODS
  申请人：Fisahn Andre

  公开号：US20210038589A1

  公开（公告）日：2021-02-11

  The present invention relates generally to calcium channel inhibitors for use in treating and/or preventing an amyloid disease of the nervous system. The invention also relates to related pharmaceutical compositions, kits and screening methods.
• T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF
  申请人：Praxis Precision Medicines, inc.

  公开号：US20210128537A1

  公开（公告）日：2021-05-06

  Described herein are compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy) and mood disorders. The present invention further comprises methods for modulating the function of a T-type calcium channel.