8-(3-Dimethylamino-propoxy)-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione | 80539-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-(3-Dimethylamino-propoxy)-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione
• 英文别名: 8-[3-(dimethylamino)propoxy]-1,3,7-trimethylpurine-2,6-dione
• CAS: 80539-94-2；84984-05-4
• 化学式: C₁₃H₂₁N₅O₃
• 分子量: 295.34
• InChiKey: LIYPIYBPJXKPIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  70.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-(3-Dimethylamino-propoxy)-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione 生成 (E)-but-2-enedioic acid;8-[3-(dimethylamino)propoxy]-1,3,7-trimethylpurine-2,6-dione
  参考文献：
  名称：

  KLOSA, JOSEF;KROGER, HANS

  摘要：

  DOI：

文献信息

• [EN] ETHYNYLXANTHINES, PREPARATION AND USE AS CALCIUM ION CHANNEL MODULATORS<br/>[FR] ÉTHYNYLXANTHINES, PRÉPARATION ET UTILISATION DE CES COMPOSÉS EN TANT QUE MODULATEURS DES CANAUX CALCIQUES
  申请人：LATVIAN INST ORGANIC SYNTHESIS

  公开号：WO2016159747A1

  公开（公告）日：2016-10-06

  The present invention relates to novel pharmaceutical compounds, which exhibit ability to act as calcium ion channel modulators, methods for their synthesis and the treatment and/or prevention of various diseases and disorders including deregulated calcium ion channel activity.

  本发明涉及一类新颖的药物化合物，这些化合物表现出作为钙离子通道调节剂的能力，以及它们的合成方法，以及用于治疗和/或预防包括钙离子通道活性失调在内的各种疾病和障碍。
• KLOSA, J.;KROEGER, H.
  作者：KLOSA, J.、KROEGER, H.

  DOI：——

  日期：——
• US4416878A
  申请人：——

  公开号：US4416878A

  公开（公告）日：1983-11-22
• [EN] ETHYNYLXANTHINES, PREPARATION AND USE FOR CANCER TREATMENT<br/>[FR] ETHYNYLXANTHINES, LEURS PRÉPARATIONS ET LEURS UTILISATIONS POUR TRAITER LE CANCER
  申请人：LATVIAN INST ORGANIC SYNTHESIS

  公开号：WO2016159745A1

  公开（公告）日：2016-10-06

  The present invention relates to novel ethynylxanthine derivatives of formula (I) which exhibit high antiproliferative activity against various tumor cell lines, methods for their synthesis and use for the treatment and/or prevention of cancer.
• [EN] NOVEL ETHYNYLXANTHINES, THEIR PREPARATION AND USE AS INHIBITORS OF MATRIX METALLOPROTEINASES AND ANGIOGENESIS<br/>[FR] NOUVELLES ÉTHYNYLXANTHINES, LEUR PRÉPARATION ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE MÉTALLOPROTÉINASES MATRICIELLES ET D'ANGIOGENÈSE
  申请人：LATVIAN INST ORGANIC SYNTHESIS

  公开号：WO2016159746A1

  公开（公告）日：2016-10-06

  The present invention relates to a novel ethynylxanthine derivatives of formula (I) which exhibit ability selectively suppress matrix metalloproteinases and therefore may act as inhibitors of angiogenesis, methods for their synthesis and use for the treatment and/or prevention of various diseases and disorders caused by overexpression of matrix metalloproteinases by administration of such substances.