Epitestosterone sulfate | 4579-56-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Epitestosterone sulfate
• 英文别名: [(8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] hydrogen sulfate
• CAS: 4579-56-0
• 化学式: C₁₉H₂₈O₅S
• 分子量: 368.494
• InChiKey: WAQBISPOEAOCOG-KZYORJDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  表睾酮 在 1,2-丙二醇 、 human adrenal hydroxysteroid sulfotransferase (EC 2.8.2.2) 、 6-氨基-9-[3-羟基-5-[(羟基-磺基氧基-磷酰)氧基甲基]-4-膦酰氧基-四氢呋喃-2-基]-嘌呤 作用下， 反应 0.17h， 生成 Epitestosterone sulfate
  参考文献：
  名称：

  酶法合成甾族硫酸盐XVI。人肾上腺羟类固醇磺基转移酶的特异性和调控。

  摘要：

  人肾上腺的纯羟类固醇磺基转移酶（EC 2.8.2.2）对类固醇具有广泛的底物特异性。现已发现这种广泛的特异性延伸到简单的醇类。从C3开始的普通脂肪族醇作为底物，C9的分解率最高。速率增加伴随着Km的减少。与类固醇（如脱氢表雄酮）的硫化基团形成波状动力学形成鲜明对比，简单醇类的动力学属于正常的Michaelis-Menten类型。通过酶抗体和酶稳定性研究，提供了一种和相同的酶负责类固醇和简单醇的3位和17位羟基羟基的磺化作用的证据。

  DOI：

  10.1016/0039-128x(83)90023-5

文献信息

• Suspension arrays of cross-reactive oligonucleotide-based sensors
  申请人：Stojanovic N. Milan

  公开号：US20060194231A1

  公开（公告）日：2006-08-31

  Cross-reactive arrays on encoded beads are used to correlate ‘fingerprints’ of urine, serum and other biological liquids to disease states. Fluorescent hydrophobic sensors are based on nucleic acid three-way junctions, and beads may be encoded by size (could be registered by light scattering) and fluorescence in combination with flow cytometry analysis, also known as suspension array technology (SAT).

  编码珠上的交叉反应阵列用于将尿液、血清和其他生物液体的 "指纹 "与疾病状态联系起来。荧光疏水传感器以核酸三向连接为基础，珠子可通过大小（可通过光散射进行记录）和荧光与流式细胞仪分析相结合进行编码，也称为悬浮阵列技术（SAT）。
• Cross reactive arrays of three-way junction sensors for steroid determination
  申请人：——

  公开号：US20040203007A1

  公开（公告）日：2004-10-14

  This invention provides analyte sensitive oligonucleotide compositions for detecting and analyzing analytes in solution, including complex solutions using cross reactive arrays of analyte sensitive oligonucleotide compositions.
• Cross reactive arrays of three-way junction sensors for steriod determination
  申请人：Stojanovic N. Milan

  公开号：US20050019916A1

  公开（公告）日：2005-01-27

  This invention provides analyte sensitive oligonucleotide compositions for detecting and analyzing analytes in solution, including complex solutions using cross reactive arrays of analyte sensitive oligonucleotide compositions.
• Modulators of MS4A activity
  申请人：President and Fellows of Harvard College

  公开号：US20190321443A1

  公开（公告）日：2019-10-24

  Provided herein are methods of treating Alzheimer's disease, atopy, allergies, asthma, and a disease or disorder associated with neuroinflammation by modulating MS4A receptors. Also found herein are methods of modulating olfactory and gustatory properties of a substance by modulating MS4A receptors. Additionally, described herein are methods of identifying agents that are modulators of MS4A receptors.
• US7470516B2
  申请人：——

  公开号：US7470516B2

  公开（公告）日：2008-12-30