5,6,7,8-四氢萘-1-硫醇 | 79506-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 5,6,7,8-四氢萘-1-硫醇
• 英文名称: 5,6,7,8-tetrahydro-naphthalene-1-thiol
• 英文别名: 5,6,7,8-Tetrahydro-naphthalin-1-thiol；5-Mercapto-1.2.3.4-tetrahydro-naphthalin；5.6.7.8-Tetrahydro-thionaphthol-(1)；ar. Thio-α-tetralol；5-Mercapto-tetralin；Thiotetralol-(5)；5,6,7,8-Tetrahydronaphthalene-1-thiol
• CAS: 79506-62-0
• 化学式: C₁₀H₁₂S
• mdl: MFCD08361744
• 分子量: 164.271
• InChiKey: TVQPJOSLSPIRAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5,6,7,8-四氢萘-1-硫醇 在 permanganate(VII) ion 作用下， 生成 3-methanesulfonyl-phthalic acid
  参考文献：
  名称：

  v. Braun, Chemische Berichte, 1923, vol. 56, p. 2341

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氨基四氢化萘 生成 5,6,7,8-四氢萘-1-硫醇
  参考文献：
  名称：

  Krollpfeiffer et al., Chemische Berichte, 1925, vol. 58, p. 1670

  摘要：

  DOI：

文献信息

• Synthesis of arylthioacetamidoximes as potential antidepressants
  作者：Irena Červená、Marta Hrubantová、Marie Bartošová、Miroslav Protiva

  DOI：10.1135/cccc19811188

  日期：——

  Reactions of thiophenol and 16 of its derivatives with chloroacetonitrile afforded arylthioacetonitriles IVb-XXb which were treated with hydroxylamine and gave arylthioacetamidoximes IVa-XXa. Compounds VIIa-IXa, XIIa, XVIa and XVIIIa exhibited antireserpine activity in the test of ptosis in mice and compounds IXa and XVIIa in the test of reserpine hypothermia in mice.

  硫苯酚及其16种衍生物与氯乙腈反应生成芳基硫代乙腈IVb-XXb，经过氢氧胺处理后得到芳基硫代乙酰肟IVa-XXa。化合物VIIa-IXa、XIIa、XVIa和XVIIIa在小鼠睫下垂试验中表现出抗利血平活性，化合物IXa和XVIIa在小鼠利血平低体温试验中表现出活性。
• ERYTHROMYCIN DERIVATIVES AND MEDICINES CONTAINING THE SAME
  申请人：HOKURIKU SEIYAKU CO., LTD.

  公开号：EP1323726A1

  公开（公告）日：2003-07-02

  Erythromycin derivatives or salt thereof having excellent antibacterial activity against atypical acid-fast mycobacteria and useful as antibacterial agent, which is represented by the following general formula: wherein, R1 and R2 represent hydrogen atom, an alkyl group, a homocyclic or heterocyclic group, an alkyl group substituted with a homocyclic group, or an alkyl group substituted with a heterocyclic group or the like, or R1 and R2 may combine to form a homocycle or a heterocycle, R3 represents hydrogen atom or methyl group, R4 represents hydroxyl group or the like; R5 represents hydrogen atom, hydroxyl group or the like, R6 and R7 represent hydrogen atom, an alkyl group or the like; X represents NH or a group represented by N-O-R8, Y represents a group represented by O-C(=O)-R9, a cladinose derivative or the like, Z represents oxygen atom or sulfur atom, R8 and R9 represents an alkyl group, a homocyclic or heterocyclic group, an alkyl group substituted with a homocyclic group, or an alkyl group substituted with a heterocyclic group.

  红霉素衍生物或其盐对非典型耐酸霉菌具有优异的抗菌活性，可用作抗菌剂，其通式如下： 其中，R1 和 R2 代表氢原子、烷基、同环基或杂环基、被同环基取代的烷基或被杂环基取代的烷基等，或 R1 和 R2 可结合形成同环或杂环，R3 代表氢原子或甲基，R4 代表羟基等；R5 代表氢原子、羟基或类似物，R6 和 R7 代表氢原子、烷基或类似物；X 代表 NH 或由 N-O-R8 表示的基团，Y 代表由 O-C(＝O)-R9、克拉丁糖衍生物或类似物表示的基团，Z 代表氧原子或硫原子，R8 和 R9 代表烷基、同环基或杂环基、被同环基取代的烷基或被杂环基取代的烷基。
• NOVEL ALKYLENE DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：EP3059225A1

  公开（公告）日：2016-08-24

  The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound. A compound of formula (I): wherein R1 is substituted or unsubstituted fused aromatic heterocyclyl etc., ring A is substituted or unsubstituted non-aromatic carbocycle etc., -L1- is -O-(CR6R7)m- etc., -L2- is -O-(CR6R7)n- etc., each R6 and R7 are independently hydrogen, halogen etc., R2 is substituted or unsubstituted alkyl, R3 is hydrogen or substituted or unsubstituted alkyl, R4 is substituted or unsubstituted alkylcarbonyl etc..

  本发明的目的是提供具有 ACC2 抑制活性的新型化合物。 此外，本发明的目的是提供包含该化合物的药物组合物。 式（I）化合物：其中 R1 是取代或未取代的融合芳香杂环等，环 A 是取代或未取代的非芳香碳环等、 -L1-是-O-(CR6R7)m-等，-L2-是-O-(CR6R7)n-等，每个 R6 和 R7 独立地是氢、卤素等，R2 是取代或未取代的烷基，R3 是氢或取代或未取代的烷基，R4 是取代或未取代的烷基羰基等。
• Organic semiconductor formulations
  申请人：Flexterra, Inc.

  公开号：US10043978B2

  公开（公告）日：2018-08-07

  The present teachings relate to organic semiconductor formulations including an organic semiconducting compound in a liquid medium, where the liquid medium includes (1) a compound in liquid state that has electronic properties complementary to the electronic structure of the organic semiconducting compound and optionally (2) a solvent or solvent mixture for solubilizing the organic semiconducting compound. The present formulations can be used as inks in the fabrication of organic semiconductor devices.

  本发明涉及有机半导体制剂，包括液体介质中的有机半导体化合物，其中液体介质包括（1）液态化合物，该化合物具有与有机半导体化合物电子结构互补的电子特性，以及（2）用于溶解有机半导体化合物的溶剂或溶剂混合物。本制剂可用作制造有机半导体器件的油墨。
• Erythromycin derivative and medicament comprising the same
  申请人：——

  公开号：US20040127433A1

  公开（公告）日：2004-07-01

  Erythromycin derivatives or salt thereof having excellent antibacterial activity against a typical acid-fast mycobacteria and useful as antibacterial agent, which is represented by the following general formula: 1 wherein, R 1 and R 2 represent hydrogen atom, an alkyl group, a homocyclic or heterocyclic group, an alkyl group substituted with a homocyclic group, or an alkyl group substituted with a heterocyclic group or the like, or R 1 and R 2 may combine to form a homocycle or a heterocycle, R 3 represents hydrogen atom or methyl group, R 4 represents hydroxyl group or the like; R 5 represents hydrogen atom, hydroxyl group or the like, R 6 and R 7 represent hydrogen atom, an alkyl group or the like; X represents NH or a group represented by N—O—R 8 , Y represents a group represented by O—C(═O)—R 9 , a cladinose derivative or the like, Z represents oxygen atom or sulfur atom, R 8 and R 9 represents an alkyl group, a homocyclic or heterocyclic group, an alkyl group substituted with a homocyclic group, or an alkyl group substituted with a heterocyclic group.

  红霉素衍生物或其盐对典型的耐酸霉菌具有极佳的抗菌活性，可用作抗菌剂，其通式如下： 1 其中，R 1 和 R 2 代表氢原子、烷基、同环基或杂环基、被同环基取代的烷基或被杂环基取代的烷基等，或 R 1 和 R 2 可结合形成均环或杂环，R 3 代表氢原子或甲基，R 4 代表羟基或类似物；R 5 代表氢原子、羟基或类似物，R 6 和 R 7 代表氢原子、烷基或类似物；X 代表 NH 或由 N-O-R 8 代表的基团；Y 代表 O-C（═O）-R 9 Z 代表氧原子或硫原子，R 8 和 R 9 代表烷基、同环基或杂环基、被同环基取代的烷基或被杂环基取代的烷基。