5,6-二氟-3-氰基吲唑 | 885278-36-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 中文名称: 5,6-二氟-3-氰基吲唑
• 中文别名: 5,6-二氟-1H-吲唑-3-甲腈
• 英文名称: 5,6-difluoro-1H-indazole-3-carbonitrile
• CAS: 885278-36-4
• 化学式: C₈H₃F₂N₃
• mdl: MFCD07371571
• 分子量: 179.129
• InChiKey: ONSCTUARADANFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,6-二氟-3-氰基吲唑 、 (3-carbamoyl-5-fluoro-indazol-1-yl)-acetic acid 反应 0.04h， 生成 (3-carbamoyl-5,6-difluoroindazol-1-yl)acetic acid
  参考文献：
  名称：

  PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS

  摘要：

  本发明提供一种式（I）的化合物，一种制造本发明化合物的方法，以及其作为补体途径调节剂治疗眼部疾病的治疗用途。本发明还提供了一种药理活性剂的组合和制药组合物。

  公开号：

  US20150190457A1

文献信息

• [EN] PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS<br/>[FR] DÉRIVÉS PYRROLIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE LA VOIE DU COMPLÉMENT
  申请人：NOVARTIS AG

  公开号：WO2014002054A1

  公开（公告）日：2014-01-03

  The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种化合物(I)的方法，用于制造该发明的化合物，并将其用作眼部疾病治疗的补体途径调节剂。本发明还提供了一种药理活性剂的组合和制药组合物。
• PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS
  申请人：NOVARTIS AG

  公开号：US20150190457A1

  公开（公告）日：2015-07-09

  The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供一种式（I）的化合物，一种制造本发明化合物的方法，以及其作为补体途径调节剂治疗眼部疾病的治疗用途。本发明还提供了一种药理活性剂的组合和制药组合物。
• Active OLED display, method for preparing an active OLED display and compound
  申请人：Novaled GmbH

  公开号：US11201306B2

  公开（公告）日：2021-12-14

  The present invention relates to a display device comprising—a plurality of OLED pixels comprising at least two OLED pixels, the OLED pixels comprising an anode, a cathode, and a stack of organic layers, wherein the stack of organic layers—is arranged between and in contact with the cathode and the anode, and—comprises a first electron transport layer, a first hole transport layer, and a first light emitting layer provided between the first hole transport layer and the first electron transport layer, and—a driving circuit configured to separately driving the pixels of the plurality of OLED pixels, wherein, for the plurality of OLED pixels, the first hole transport layer is provided in the stack of organic layers as a common hole transport layer shared by the plurality of OLED pixels, and the first hole transport layer comprises (i) at least one first hole transport matrix compound consisting of covalently bound atoms and (ii) at least one electrical p-dopant selected from metal salts and from electrically neutral metal complexes comprising a metal cation and at least one anion and/or at least one anionic ligand consisting of at least 4 covalently bound atoms, wherein the metal cation of the electrical p-dopant is selected from alkali metals; alkaline earth metals, Pb, Mn, Fe, Co, Ni, Zn, Cd; rare earth metals in oxidation state (II) or (III); Al, Ga, In; and from Sn, Ti, Zr, Hf, V, Nb, Ta, Cr, Mo and W in oxidation state (IV) or less, a method for preparing the display device and a chemical compound for use therein.

  本发明涉及一种显示装置，包括-多个 OLED 像素，该多个 OLED 像素包括至少两个 OLED 像素，该 OLED 像素包括阳极、阴极和有机层堆叠，其中有机层堆叠-布置在阴极和阳极之间并与阴极和阳极接触，并且-包括第一电子传输层、第一空穴传输层和设置在第一空穴传输层和第一电子传输层之间的第一发光层，以及-驱动电路，该驱动电路被配置为分别驱动多个 OLED 像素中的像素，其中、对于多个 OLED 像素，第一空穴传输层作为多个 OLED 像素共享的共用空穴传输层被设置在有机层堆叠中、第一空穴传输层包括：(i) 至少一种由共价结合原子组成的第一空穴传输基质化合物；(ii) 至少一种选自金属盐和电中性金属复合物的电 p-掺杂剂，电中性金属复合物包括金属阳离子和至少一种阴离子和/或至少一种由至少 4 个共价结合原子组成的阴离子配体，其中电 p-掺杂剂的金属阳离子选自碱金属碱土金属、Pb、Mn、Fe、Co、Ni、Zn、Cd；氧化态（II）或（III）的稀土金属；Al、Ga、In；以及氧化态（IV）或更低的Sn、Ti、Zr、Hf、V、Nb、Ta、Cr、Mo和W。
• Electronic semiconducting device and method for preparing the electronic semiconducting device
  申请人：Novaled GmbH

  公开号：US11239440B2

  公开（公告）日：2022-02-01

  The present invention relates to an electronic device comprising between a first electrode and a second electrode at least one first hole transport layer, wherein the first hole transport layer comprises (i) at least one first hole transport matrix compound consisting of covalently bound atoms and (ii) at least one electrical p-dopant selected from metal sate and from electrically neutral metal complexes comprising a metal cation and a at least one anion and/or at least one anionic ligand consisting of at least 4 covalently bound atoms, wherein the metal cation of the electrical p-dopant is selected from alkali metals; alkaline earth metals, Pb, Me, Fe, Co, Ni, Zn, Cd; rare earth metals in oxidation state (II) or (III); Al, Ga, In; and from Sn, Ti, Zr, Hf, V, Nb, Ta, Cr, Mo and W in oxidation state (TV) or less; provided that a) p-dopants comprising anion or anionic ligand having generic formula (Ia) or (Ib) wherein A1, A2, A3 and A4 are independently selected from CO, SO2 or POR1; R1=electron withdrawing group selected from the group comprising halide, nitrile, halogenated or perhalogenated C1 to C20 alkyl, halogenated or perhalogenated C6 to C20 aryl, or halogenated or perhalogenated heteroaryl with 5 to 20 ring-forming atoms; B1, B2, B3 and B4 are same or independently selected from substituted or unsubstituted C1 to C20 alkyl, substituted or unsubstituted C1 to C20 heteroalkyl, substituted or unsubstituted C6 to C20 aryl, substituted or unsubstituted C5 to C20 heteroaryl, or B1 and B2 form a ring; and b) p-dopants consisting of Li cation and an anion selected from perchlorate and tetrafluoroborate are excluded, and the first hole transport layer comprises a sublayer, wherein the electrical dopant is comprised in an amount, by weight and/or by volume, exceeding the total amount of other components which may additionally be comprised in the sublayer, and a method for preparing the same.

  本发明涉及一种电子器件，在第一电极和第二电极之间包括至少一个第一空穴传输层，其中第一空穴传输层包括(i)至少一个由共价结合原子组成的第一空穴传输基质化合物和(ii)至少一个电p-掺杂剂，该电p-掺杂剂选自金属酸盐和电中性金属络合物，该金属络合物包括一个金属阳离子和至少一个阴离子和/或至少一个由至少4个共价结合原子组成的阴离子配体，其中电p-掺杂剂的金属阳离子选自碱金属、碱土金属、铅、锰、铁、钴、镍、锌、镉；氧化态(II)或(III)的稀土金属；Al、Ga、In；以及Sn、Ti、Zd；碱土金属、Pb、Me、Fe、Co、Ni、Zn、Cd；氧化态为 (II) 或 (III) 的稀土金属；Al、Ga、In；以及氧化态为 (TV) 或以下的 Sn、Ti、Zr、Hf、V、Nb、Ta、Cr、Mo 和 W；条件是 a) p 掺杂剂包含具有通式 (Ia) 或 (Ib) 的阴离子或阴离子配体，其中 A1、A2、A3 和 A4 独立选自 CO、SO2 或 POR1；R1=从卤化物、腈、卤代或过卤代的 C1 至 C20 烷基、卤代或过卤代的 C6 至 C20 芳基或卤代或过卤代的具有 5 至 20 个成环原子的杂芳基所组成的组中选出的取电子基团；B1、B2、B3 和 B4 相同或独立选自取代或未取代的 C1 至 C20 烷基、取代或未取代的 C1 至 C20 杂烷基、取代或未取代的 C6 至 C20 芳基、取代或未取代的 C5 至 C20 杂芳基，或 B1 和 B2 形成一个环；b) 不包括由锂阳离子和选自高氯酸盐和四氟硼酸盐的阴离子组成的 p 掺杂剂，且第一空穴传输层包括一个子层，其中电掺杂剂的含量（按重量和/或体积计）超过子层中可能另外包含的其他成分的总量，以及制备该掺杂剂的方法。
• Electronic device, method for preparing the same and display device comprising the same
  申请人：Novaled GmbH

  公开号：US11522150B2

  公开（公告）日：2022-12-06

  The present invention relates to an electronic device comprising at least one layer comprising a borate salt, wherein the borate salt is comprised in the layer comprising the borate salt In an amount, by weight and/or by volume, exceeding the total amount of other components which may additionally be comprised in the layer, a display device comprising the same and a method for preparing the same.

  本发明涉及一种包含至少一层硼酸盐的电子器件，其中硼酸盐在包含硼酸盐的层中的含量（按重量和/或体积计算）超过了可能另外包含在层中的其他成分的总量；还涉及一种包含该电子器件的显示设备和制备该电子器件的方法。