2,2-dimethyl-5-hydroxy-3-(3-oxobutyl)-7-pentyl-4-chromone | 85700-57-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,2-dimethyl-5-hydroxy-3-(3-oxobutyl)-7-pentyl-4-chromone
• 英文别名: cannabichromanone；cannabichromanon；CBCN；5-hydroxy-2,2-dimethyl-3-(3-oxo-butyl)-7-pentyl-chroman-4-one；Cannabicromanon；5-hydroxy-2,2-dimethyl-3-(3-oxobutyl)-7-pentyl-3H-chromen-4-one
• CAS: 85700-57-8
• 化学式: C₂₀H₂₈O₄
• 分子量: 332.44
• InChiKey: NHZMSIOYBVIOAF-UHFFFAOYSA-N

物化性质

• 沸点：
  491.4±45.0 °C(Predicted)
• 密度：
  1.069±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,3-二甲基丙烯酸 在 三氟化硼 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 68.0h， 生成 2,2-dimethyl-5-hydroxy-3-(3-oxobutyl)-7-pentyl-4-chromone
  参考文献：
  名称：

  Synthesis of 2,2-dimethyl-5-hydroxy-3-(3-oxobutyl)-7-pentyl-4-chromone

  摘要：

  DOI：

  10.1007/bf00809382

文献信息

• Cannabis oil extracts and compositions
  申请人：CONSTANCE THERAPEUTICS, INC.

  公开号：US10406186B2

  公开（公告）日：2019-09-10

  The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.

  本发明提供了大麻油提取物及其组合物，包括含有维生素 E 的大麻油组合物，以及制备提取物和组合物的方法。在一些实施方案中，本发明提供了一种制备大麻油提取物的方法，包括用溶剂从大麻植物材料中洗脱大麻素以产生洗脱液，用过滤器过滤洗脱液以产生滤液，用蒸馏器蒸发滤液中的溶剂以产生蒸馏物，在足以除去残留溶剂的条件下净化蒸馏物，从而制备提取物。在某些实施方案中，该方法还包括将一定量的维生素 E 与萃取物混合，制成大麻油组合物。
• Bioactive concentrates and uses thereof
  申请人：SC LABORATORIES, INC.

  公开号：US10792318B2

  公开（公告）日：2020-10-06

  The present invention relates to concentrates obtained from extraction from Cannabis, preferably cannabinoid and/or terpene concentrates, and formulation of the concentrates, particularly for use for direct vaporization, infusion into edible matrices, in electronic inhalation devices, and as nutraceuticals.

  本发明涉及从大麻中提取的浓缩物，最好是大麻素和/或萜类浓缩物，以及浓缩物的配方，特别是用于直接汽化、注入可食用基质、电子吸入装置和作为营养保健品。
• Methods and compositions for treating cancer
  申请人：Sutter West Bay Hospitals

  公开号：US11344527B2

  公开（公告）日：2022-05-31

  This disclosure provides compositions and method useful for treating cell proliferative disorders including cancer. The disclosure provides cannabidiol derivatives and compositions thereof either alone or in combination with THC or a derivative thereof.

  本公开提供了用于治疗包括癌症在内的细胞增殖性疾病的组合物和方法。本公开提供了大麻二酚衍生物及其单独或与四氢大麻酚或其衍生物结合使用的组合物。
• Chiodini, Laura; Ciommo, Mauro Di; Merlini, Lucio, Heterocycles, 1981, vol. 16, # 11, p. 1899 - 1900
  作者：Chiodini, Laura、Ciommo, Mauro Di、Merlini, Lucio

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS FOR TREATING CANCER
  申请人：McAllister Sean D.

  公开号：US20100204312A1

  公开（公告）日：2010-08-12

  This disclosure provides compositions and method useful for treating cell proliferative disorders including cancer. The disclosure provides cannabidiol derivatives and compositions thereof either alone or in combination with THC or a derivative thereof.