6-hydroxy-6-(2-oxocyclopentyl)indolo[2,1-b]quinazolin-12-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-hydroxy-6-(2-oxocyclopentyl)indolo[2,1-b]quinazolin-12-one
• 英文别名: 6-Hydroxy-6-(2-oxocyclopentyl)indolo[2,1-b]-quinazolin-12-one
• 化学式: C₂₀H₁₆N₂O₃
• 分子量: 332.359
• InChiKey: NRHPRGPVMBPMKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  色胺酮 、 环戊酮 在 potassium carbonate 作用下， 以 乙醇 、 甘油 为溶剂， 以95%的产率得到6-hydroxy-6-(2-oxocyclopentyl)indolo[2,1-b]quinazolin-12-one
  参考文献：
  名称：

  Synthesis and antimicrobial activity of tryptanthrin adducts with ketones

  摘要：

  Reactions of tryptanthrin with acetone, cyclopentanone, hexan-2-one, 4-methylpentan-2-one, 4-hydroxy-4-methylpentan-2-one, cyclohexanone, and butan-2-one in the presence of potassium carbonate afforded racemic phaitanthrin A and other addition products to the ketone group of tryptanthrin with high yields. Thermal dissociation, some chemical transformations, and antimicrobial activity of some adducts were studied, and inhibitory effect against gram-positive bacteria was found for particular derivatives.

  DOI：

  10.1134/s1070428017030174

文献信息

• Synthesis and antimicrobial activity of tryptanthrin adducts with ketones
  作者：P. I. Deryabin、T. V. Moskovkina、L. S. Shevchenko、A. I. Kalinovskii

  DOI：10.1134/s1070428017030174

  日期：2017.3

  Reactions of tryptanthrin with acetone, cyclopentanone, hexan-2-one, 4-methylpentan-2-one, 4-hydroxy-4-methylpentan-2-one, cyclohexanone, and butan-2-one in the presence of potassium carbonate afforded racemic phaitanthrin A and other addition products to the ketone group of tryptanthrin with high yields. Thermal dissociation, some chemical transformations, and antimicrobial activity of some adducts were studied, and inhibitory effect against gram-positive bacteria was found for particular derivatives.