6-Aminohexahydrofuro[3,2-b]furan-3-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: 6-Aminohexahydrofuro[3,2-b]furan-3-ol
• 英文别名: 3-amino-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-ol
• 化学式: C₆H₁₁NO₃
• 分子量: 145.16
• InChiKey: NTIGTCIZCBNMIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PROCESS FOR THE HOMOGENEOUSLY CATALYZED AMINATION OF ALCOHOLS WITH AMMONIA IN THE PRESENCE OF A COMPLEX CATALYST WHICH COMPRISES NO ANIONIC LIGANDS
  申请人：BASF SE

  公开号：US20140024833A1

  公开（公告）日：2014-01-23

  The invention relates to a process for preparing primary amines by alcohol amination of alcohols with ammonia with the elimination of water, where the alcohol amination is carried out under homogeneous catalysis in the presence of at least one complex catalyst which comprises ruthenium and at least one at least bidental donor ligand, but no anionic ligands.

  本发明涉及一种通过醇胺化反应制备一级胺的方法，其中使用氨将醇胺化反应中的水排除，该醇胺化反应在至少一种复合催化剂的存在下进行均相催化，所述复合催化剂包括铑和至少一种双齿或更多齿配体，但不包括阴离子配体。
• METHOD FOR PRODUCING MULTICYCLICAL RING SYSTEMS CARRYING AMINO GROUPS
  申请人：Sieber Volker

  公开号：US20120041216A1

  公开（公告）日：2012-02-16

  The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.

  本发明涉及一种方法，使用至少一种具有转氨酶活性的酶E，将至少一个含有酮基的多环环系统中的酮基氨化成氨基。
• ISOMANNIDE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
  申请人：SANOFI

  公开号：US20150336979A1

  公开（公告）日：2015-11-26

  The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, inflammation or could show beneficial effects in pain, dyslipidemia and atherosclerosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

  本发明涉及式(I)的化合物，其中R1，R11，R12和X具有声明中指示的含义。公式I的化合物是有价值的药理活性化合物。它们是高效、选择性可溶性环氧酶抑制剂，适用于肾衰竭、糖尿病性肾病、2型糖尿病、炎症的治疗和预防，或者在疼痛、血脂异常和动脉粥样硬化方面可能显示出有益的效果。本发明还涉及制备式(I)化合物的方法，它们的用途，特别是作为药物中的活性成分，以及包含它们的制药制剂。
• VERFAHREN ZUR HOMOGEN-KATALYSIERTEN AMINIERUNG VON ALKOHOLEN MIT AMMONIAK IN GEGENWART EINES KOMPLEXKATALYSATORS OHNE ANIONISCHE LIGANDEN
  申请人：BASF SE

  公开号：EP2875027B1

  公开（公告）日：2018-05-02
• SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS
  申请人：Evotec International GmbH

  公开号：EP2917185B1

  公开（公告）日：2017-05-10