2,2,5-trimethyl-3,4-dihydro-2H-benzo[h]chromen-6-ol | 4380-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 2,2,5-trimethyl-3,4-dihydro-2H-benzo[h]chromen-6-ol
• 英文别名: 2,2,5-Trimethyl-3,4-dihydro-2H-benzochromen-6-ol；2,2,5-Trimethyl-3,4-dihydrobenzo[h]chromen-6-ol
• CAS: 4380-13-6
• 化学式: C₁₆H₁₈O₂
• 分子量: 242.318
• InChiKey: MLTCNWDXQSZNKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-dimethoxy-2-methyl-3-(γ-hydroxy-isopentyl)-naphthalene 在 氢溴酸 、 溶剂黄146 作用下， 生成 2,2,5-trimethyl-3,4-dihydro-2H-benzo[h]chromen-6-ol
  参考文献：
  名称：

  Effects of phosphate fertilizer levels on cowpea pod-sucking bug populations and damage

  摘要：

  The effect of different application levels of phosphate fertilizer on cowpea pod-sucking bugs [Clavigralla sp., Riptortus sp., Anoplocnemis., Mirperus sp. and Negara sp. (Heteroptera)] was studied using 0 (control), 20, 40 and 60 kg/ha of single super-phosphate. The results showed that the bug densities decreased significantly with increase in rate of application. At 40 and 60 kg/ha, grain yields were significantly higher than at the lower rates of application. Crude protein, fibre, oxalate, phytin, potassium and magnesium contents as well as seed hardness also increased with increase in the rate of fertilizer application.

  DOI：

  10.1080/096708700415544

文献信息

• Synthesis and Radical Scavenging Activity of Substituted Benzo[h]chromanols
  作者：Keiko Inami、Yuta Okayama、Masanori Harada、Mine Morita、Masataka Mochizuki

  DOI：10.3987/com-17-13671

  日期：——

  Benzo[h]chromanols, which possess a tocopherol moiety, have been reported to exhibit potent antioxidant activity. Several benzo[h]chromanols with various substituents (nitro, chloro, bromo, methyl, or amino groups at the position ortho to the phenolic OH group) were synthesized, and the second-order rate constants (k) of their reaction with the galvinoxyl radical were determined. The introduction of electron-withdrawing bromo, chloro and nitro groups decreased the activity, and the activity correlated well with the substituent effect. ortho-Aminobenzo[h]chromanol showed the highest radical scavenging activity among the compounds synthesized.
• PHARMACEUTICALLY ACTIVE COMPOSITIONS COMPRISING OXIDATIVE STRESS MODULATORS (OSM), NEW CHEMICAL ENTITIES, COMPOSITIONS AND USES
  申请人：Basu Hirak S.

  公开号：US20100297262A1

  公开（公告）日：2010-11-25

  Described herein are pharmaceutical compositions and medicaments, and methods of using such pharmaceutical compositions and medicaments in the treatment of inflammation and cancer.