N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-3,4-dibromomaleimide | 1442447-55-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-3,4-dibromomaleimide
• 英文别名: 3,4-Dibromo-Mal-PEG3-Azide；1-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-3,4-dibromopyrrole-2,5-dione
• CAS: 1442447-55-3
• 化学式: C₁₂H₁₆Br₂N₄O₅
• 分子量: 456.091
• InChiKey: KTSDWAOFRFJZLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  甲基3,4-二溴-2,5-二氧代-2H-吡咯-1(5H)-羧酸叔丁酯 、 1-氨基-11-叠氮-3,6,9-三氧杂十一烷 以 二氯甲烷 为溶剂， 反应 0.5h， 以80%的产率得到N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-3,4-dibromomaleimide
  参考文献：
  名称：

  A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

  摘要：

  Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomaleimides and bromopyridazinediones. (c) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.088

文献信息

• A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones
  作者：Lourdes Castañeda、Zoë V.F. Wright、Cristina Marculescu、Trang M. Tran、Vijay Chudasama、Antoine Maruani、Elizabeth A. Hull、João P.M. Nunes、Richard J. Fitzmaurice、Mark E.B. Smith、Lyn H. Jones、Stephen Caddick、James R. Baker

  DOI：10.1016/j.tetlet.2013.04.088

  日期：2013.7

  Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomaleimides and bromopyridazinediones. (c) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.