HIV-1 tat Protein (47-57) trifluoroacetate salt H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH trifluoroacetate salt

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: HIV-1 tat Protein (47-57) trifluoroacetate salt H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH trifluoroacetate salt
• 英文别名: 2-[[2-[[2-[[5-amino-2-[[2-[[2-[[6-amino-2-[[6-amino-2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
• 化学式: C₆₄H₁₁₈N₃₂O₁₄
• 分子量: 1559.8
• InChiKey: RAVVEEJGALCVIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -11.3
• 重原子数：
  110
• 可旋转键数：
  64
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  841
• 氢给体数：
  34
• 氢受体数：
  23

文献信息

• [EN] METHODS AND COMPOSITIONS FOR INHIBITING ABAD/Aß PROTEIN INTERACTION<br/>[FR] PROCEDES ET COMPOSITIONS POUR INHIBER L'INTERACTION ENTRE L'ENZYME ABAD ET LA PROTEINE A DOLLAR G(B)
  申请人：UNIV COLUMBIA

  公开号：WO2005117538A2

  公开（公告）日：2005-12-15

  This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aβ protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer’s disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell.
• [EN] METHODS AND COMPOSITIONS FOR INHIBITING ABAD/Aß PROTEIN INTERACTION<br/>[FR] PROCEDES ET COMPOSITIONS POUR INHIBER L'INTERACTION ENTRE L'ENZYME ABAD ET LA PROTEINE A$G(B)
  申请人：UNIV COLUMBIA

  公开号：WO2005117538A9

  公开（公告）日：2006-12-07

  [EN] This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aß protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer's disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell.
  [FR] Cette invention concerne des procédés, des compositions et des produits destinés à inhiber la liaison entre la protéine Aß et l'enzyme ABAD dans des cellules. Les utilisations de cette invention sont notamment le traitement de la maladie d'Alzheimer, la réduction de la production de radicaux libres, de la fragmentation d'ADN et de la libération des cytochromes C dans des cellules, et la préservation de la viabilité des cellules en empêchant la libération de LDH d'une cellule.