8-butoxy-7-methoxynaphthalen-2-ol | 1420804-87-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-butoxy-7-methoxynaphthalen-2-ol
• 英文别名: 8-Butoxy-7-methoxynaphthalen-2-ol
• CAS: 1420804-87-0
• 化学式: C₁₅H₁₈O₃
• 分子量: 246.306
• InChiKey: ZOLLGCVNGMIGOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  o-allylphenol 在 氧气 、 copper dichloride 、 palladium dichloride 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 15.0h， 以80%的产率得到8-butoxy-7-methoxynaphthalen-2-ol
  参考文献：
  名称：

  One-pot access to 2-naphthols and benzofurans via the aerobic Wacker-type oxidation/intramolecular aldol cyclization

  摘要：

  An aerobic Wacker-type oxidation/intramolecular aldol cyclization synthetic route toward two oxygenated 2-naphthols 3 and benzofurans 4 starting with skeleton 2 with good yields is described. The route has been carried by the one-pot transformation of the regioselective PdCl2/CuCl2-mediated Wacker oxidative cyclization of skeleton 2 with molecular oxygen under the alkaline methanolic condition. Skeleton 2 was prepared from skeleton 1 in moderate total yields via the known protocol. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.12.009

文献信息

• One-pot access to 2-naphthols and benzofurans via the aerobic Wacker-type oxidation/intramolecular aldol cyclization
  作者：Meng-Yang Chang、Chieh-Kai Chan、Shin-Ying Lin

  DOI：10.1016/j.tet.2012.12.009

  日期：2013.2

  An aerobic Wacker-type oxidation/intramolecular aldol cyclization synthetic route toward two oxygenated 2-naphthols 3 and benzofurans 4 starting with skeleton 2 with good yields is described. The route has been carried by the one-pot transformation of the regioselective PdCl2/CuCl2-mediated Wacker oxidative cyclization of skeleton 2 with molecular oxygen under the alkaline methanolic condition. Skeleton 2 was prepared from skeleton 1 in moderate total yields via the known protocol. (c) 2012 Elsevier Ltd. All rights reserved.