1-(1,3-benzodioxol-5-yl)-N-[2-(3-fluorophenyl)ethyl]-9H-beta-carboline-3-carboxamide

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 1-(1,3-benzodioxol-5-yl)-N-[2-(3-fluorophenyl)ethyl]-9H-beta-carboline-3-carboxamide
• 英文别名: 1-(1,3-benzodioxol-5-yl)-N-[2-(3-fluorophenyl)ethyl]-9H-pyrido[3,4-b]indole-3-carboxamide
• 化学式: C₂₇H₂₀FN₃O₃
• 分子量: 453.5
• InChiKey: RTNXAJWXCVFVJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  76.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• INHIBITORS OF STORE OPERATED CALCIUM RELEASE
  申请人：Whitten Jeffrey P.

  公开号：US20100087415A1

  公开（公告）日：2010-04-08

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
• US8143269B2
  申请人：——

  公开号：US8143269B2

  公开（公告）日：2012-03-27