3,4'-Dihydroxystilben | 62574-04-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3,4'-Dihydroxystilben
• 英文别名: 3-[2-(4-Hydroxyphenyl)ethenyl]phenol
• CAS: 62574-04-3
• 化学式: C₁₄H₁₂O₂
• 分子量: 212.248
• InChiKey: UFGKEFGYNRJIGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  12-hydroxy-3-methoxystilbene 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 3,4'-Dihydroxystilben
  参考文献：
  名称：

  TRPA1 channels as targets for resveratrol and related stilbenoids

  摘要：

  A series of twenty resveratrol analogues was synthesized and tested on TRPA1 and TRPV1 channels. None was able to significantly modulate TRPV1 channels. Conversely, most of them exhibited remarkably higher TRPA1 modulating activity than resveratrol. Optimal potency was observed with ortho monoxy-genated stilbenes 6 and 17. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.12.065

文献信息

• MOLECULARLY IMPRINTED POLYMERS
  申请人：Hearn Milton T. W.

  公开号：US20120052757A1

  公开（公告）日：2012-03-01

  The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.

  本发明提供了设计分子印迹聚合物（MIPs）的方法，这些方法在从各种生物加工原料和废弃物中提取生物活性化合物方面具有应用。本发明进一步针对由本发明方法设计的MIPs。
• Anti-proliferative composition
  申请人：Nutricia N.V.

  公开号：EP1314438A1

  公开（公告）日：2003-05-28

  Non-estrogen-dependent hyperproliferation of cells in animals or humans can be prevented or treated by means of a pharmaceutical or nutritional composition containing a combination of a) two or more inhibitors of the G1/S phase of the cell cycle; and b) two or more inhibitors of the G2/M phase of the cell cycle; and c) two or more inhibitors of protein tyrosine kinase activity. Especially, component a) comprises two or more compounds selected from flavanolignans, carotenoids and isoflavone; component b) comprises two or more compounds selected from flavanolignans, hydroxylated stilbenes, isoflavones and apigenin; and component c) comprises two or more compounds selected from flavanolignans and isoflavones.

  动物或人体内非雌激素依赖性细胞过度增殖可通过含有以下成分组合的药物或营养组合物来预防或治疗 a) 细胞周期 G1/S 期的两种或两种以上抑制剂；以及 b) 细胞周期 G2/M 期的两种或两种以上抑制剂；以及 c) 两种或两种以上蛋白酪氨酸激酶活性抑制剂。 特别是，成分 a) 包括两种或两种以上选自黄烷木质素、类胡萝卜素和异黄酮的化合物；成分 b) 包括两种或两种以上选自黄烷木质素、羟基化芪、异黄酮和芹菜素的化合物；成分 c) 包括两种或两种以上选自黄烷木质素和异黄酮的化合物。
• Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof
  申请人：Unigen, Inc.

  公开号：US10583161B2

  公开（公告）日：2020-03-10

  Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.

  已公开的用于骨骼健康、软骨健康或两者的组合物和方法包括制备和使用至少一种富含一种或多种前炔基黄酮的桑树提取物、至少一种富含一种或多种游离 B 环黄酮的黄芩提取物和至少一种富含一种或多种黄烷的金合欢提取物的混合物。
• Low melting and low viscosity thermoset matrix resins from the Z configuration of polyhydroxy stilbenes
  申请人：The United States of America, as represented by the Secretary of the Navy

  公开号：US10723834B1

  公开（公告）日：2020-07-28

  The invention generally relates to novel poly-substituted cis stilbenes, their synthesis, their purification, and their use in thermoset resins. These novel cis stilbenes give rise to thermoset resins with greatly improved processing characteristics such as lower melting temperature and lower viscosity; resulting in polymers and composites having greatly improved thermal stability.

  本发明一般涉及新型多取代顺式二苯乙烯、其合成、纯化及其在热固性树脂中的应用。这些新型顺式二苯乙烯可产生热固性树脂，大大改善其加工特性，如降低熔化温度和粘度，从而使聚合物和复合材料的热稳定性大大提高。
• Compositions and methods for joint health
  申请人：Unigen, Inc.

  公开号：US11123393B2

  公开（公告）日：2021-09-21

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

  本公开提供了前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物，能够调节关节炎症、关节疼痛、关节僵硬、软骨退化，或改善活动能力、活动范围、柔韧性、关节物理功能或其任意组合。这种前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物可以选择性地与其他关节调理剂结合使用，如非甾体抗炎剂/镇痛剂、COX/LOX 抑制剂、氨基葡萄糖化合物、神经性疼痛缓解剂等。