5,7-双三氟甲基-3-氰基吡唑并[1,5-a]嘧啶 | 175276-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 中文名称: 5,7-双三氟甲基-3-氰基吡唑并[1,5-a]嘧啶
• 中文别名: 5,7-双三氟甲基-3-氰基吡唑并[1,5-A]嘧啶
• 英文名称: 5,7-bis(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
• 英文别名: 5,7-Bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
• CAS: 175276-40-1
• 化学式: C₉H₂F₆N₄
• mdl: MFCD00084901
• 分子量: 280.132
• InChiKey: WVNWOBVYCHLPGW-UHFFFAOYSA-N

物化性质

• 熔点：
  75 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  9

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R20/21/22
• 海关编码：
  2933990090

文献信息

• Compounds
  申请人：——

  公开号：US20030134862A1

  公开（公告）日：2003-07-17

  The present invention relates to novel compounds which are pyrazolo[1,5-a]pyrimidines, and which modulate the activity of peroxisome proliferator-activated receptors (PPAR) &agr; and/or &ggr;. The said compounds are predicted to be useful in the treatment of metabolic diseases, e.g. type II diabetes.

  本发明涉及新型化合物，它们是吡唑并［1,5-a］嘧啶，并且调节过氧化物酶体增殖物激活受体（PPAR）α和/或γ的活性。这些化合物被预测可用于治疗代谢性疾病，例如2型糖尿病。
• HETEROCYCLIC COMPOUND
  申请人：Mochizuki Michiyo

  公开号：US20110118236A1

  公开（公告）日：2011-05-19

  An object of the present invention is to provide a novel AMPA receptor potentiator. A compound represented by the following formula (I) or a salt thereof: wherein in formula (I) R 1 represents (1) a halogen atom, or (2) cyano group, or the like; Ra and Rb each independently represent a hydrogen atom or C 1-4 alkyl; L represents a bond, or a spacer in which the number of atoms in the main chain is 1 to 8; Ring A represents (1) a non-aromatic carbon ring of 4-8 carbon atoms, or (2) a 4- to 8-membered non-aromatic heterocycle either of which is optionally substituted with 1 or more substituents selected from (a) halogen atoms, and (b) cyano group; and Ar represents a substituted phenyl group, or optionally substituted 5- or 6-membered aromatic heterocyclic group.

  本发明的目的是提供一种新型AMPA受体增强剂。化合物由以下式(I)或其盐所表示：其中在式(I)中，R1表示（1）卤素原子或（2）氰基等；Ra和Rb各自独立地表示氢原子或C1-4烷基；L表示键或主链中原子数为1至8的间隔物；环A表示（1）4-8个碳原子的非芳香碳环，或（2）4-至8个成员的非芳香杂环，其中任一环均可以选择性地用1个或多个取代基所取代，所述取代基选择自(a)卤素原子和(b)氰基；Ar表示取代苯基或可选择性取代的5-或6-成员芳香杂环基。
• [EN] PIPAZOLO [1,5-a] PYRIMIDINE DERIVATIVES AS MODULATORS OF PPAR<br/>[FR] DERIVES DE PYRAZOLO[1,5-A] PYRIMIDINE UTILISES COMME MODULATEURS DE PPAR
  申请人：BIOVITRUM AB

  公开号：WO2003053976A1

  公开（公告）日：2003-07-03

  The present invention relates to novel compounds which are pyrazolo[1,5-a] pyrimidines, and which modulate the activity of peroxisome proliferator-activited receptors (PPAR) α and/or Ϝ. The said compounds are predicted to be useful in the treatment of metabolic diseases, e.g. type II diabetes. Or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, C1-6 alkylthio, arylalkylthio, cyano-C1-6 alkyl, -C(CN)=CH-R1 or -CH(CN)-CH2-R1,