trans-6-methyl-3-hydroxytetrahydropyran | 76137-52-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: trans-6-methyl-3-hydroxytetrahydropyran
• 英文别名: (3R,6R)-6-Methyltetrahydro-2H-pyran-3-ol；(3R,6R)-6-methyloxan-3-ol
• CAS: 76137-52-5
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: IVUMRULTPACMCY-PHDIDXHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-环氧基-5-己烯 、 Acetic acid, mercury(2+) salt (2:1) 、 sodium hydroxide 、 硼氢化钠 以21%的产率得到
  参考文献：
  名称：

  BROWN H. C.; LYNCH G. J., J. ORG. CHEM., 1981, 46, NO 5, 930-939

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS AND METHODS FOR INHIBITING FIBROSIS, INFLAMMATION AND CANCER<br/>[FR] COMPOSITIONS ET MÉTHODES POUR INHIBER LA FIBROSE, L'INFLAMMATION ET LE CANCER
  申请人：GEORGIA TECH RES INST

  公开号：WO2022146980A1

  公开（公告）日：2022-07-07

  Provided herein are macrocycle-based compounds or diastereomers, solvate, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating fibrosis, inflammatory disease, and cancer.

  本文提供基于大环化合物或其对映体、溶剂化物或其药学上可接受的盐。还提供包括上述化合物的药物组合物和药物，以及治疗纤维化、炎症性疾病和癌症的方法。
• Solvomercuration-demercuration. 9. Oxymercuration-demercuration of chloro-, epoxy-, and thiomethyl-substituted alkenes
  作者：Herbert C. Brown、Gary J. Lynch

  DOI：10.1021/jo00318a019

  日期：1981.2
• [EN] MACROLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS DE MACROLIDE EN TANT QU'AGENTS ANTIBACTÉRIENS
  申请人：RANBAXY LAB LTD

  公开号：WO2008111020A2

  公开（公告）日：2008-09-18

  [EN] The present invention provides macrolide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided, are the processes for preparing the compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.
  [FR] La présente invention concerne des dérivés de macrolide qui peuvent être utilisés en tant qu'agents antibactériens. Les composés décrits dans le présent document peuvent être utilisés pour traiter ou prévenir des troubles causés par des bactéries à gram positif, à gram négatif ou anaérobies, plus particulièrement, par exemple, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae ou leurs combinaisons quelconques, ou des troubles auxquels ces bactéries contribuent. L'invention concerne également des procédés de préparation des composés décrits dans le présent document, des compositions pharmaceutiques contenant des composés décrits dans le présent document et des procédés de traitement d'infections bactériennes.
• [EN] PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING DEGENERATIVE NEUROLOGICAL DISORDERS, CONTAINING, AS ACTIVE INGREDIENT, MIXTURE EXTRACT OF MOUTAN ROOT BARK, ANGELICA DAHURICA ROOT AND BUPLEURUM ROOT OR FRACTION THEREOF<br/>[FR] COMPOSITION PHARMACEUTIQUE DESTINÉE À TRAITER ET À PRÉVENIR DES TROUBLES NEUROLOGIQUES DÉGÉNÉRATIFS CONTENANT, COMME PRINCIPE ACTIF, UN EXTRAIT DE MÉLANGE D'ÉCORCE DE RACINE DE PIVOINE ARBORESCENTE, DE RACINE D'ANGELICA DAHURICA ET DE RACINE DE BUPLEURUM OU UNE FRACTION DE CELUI-CI<br/>[KO] 목단피，백지 및 시호의 혼합 추출물 또는 이의 분획물을 유효성분으로 함유하는，신경 퇴행성 질환의 치료 및 예방용 약학적 조성물
  申请人：UNIV KYUNG HEE UNIV IND COOP GROUP

  公开号：WO2016043517A1

  公开（公告）日：2016-03-24

  . 본 발명은 목단피 (Moutan Root Bark, Moutan Radici s Cortex), 백지 (Angel ica Dahur ica Root, Angel icae Dahur i cae Radix) 및 시호 (Bupleurum Root, Bupleur i Radix)로 구성된 군으로부터 선택된 2 종 이상의 흔합 추출물 또는 이의 분획물을 유효성분으로 함유하는， 신경 퇴행성 질환의 치료 및 예방용 약학적 조성 물에 관한 것으로， 구체적으로 본 발명의 혼합 추출물은 사험관 내 ( in vi tro)에서 단독 추출물에서 나타나는 것보다 현저하게 상승한 미토콘드리아 기능 손상 회복 효과， 소포체 스트레스 완화 효과， 염증반웅 억제 효과를 동시에 나타내며， 상기 흔합 추출물은 파킨슨병 동물 모델에서 운동 협웅 (motor coordinat ion) 개선 효과 및 도파민 신경세포 보호 효과를 유의적으로 나타내므로， 본 발명의 흔합 추출물 또는 이의 분획물은 신경 퇴행성 질환 치료 및 예방용 약학적 조성물의 유효성분으 로서 유용하게 사용될 수 있다.
• [EN] IMMUNOMODULATING TRIFLUOROMETHYL-AMINAL AZALIDES<br/>[FR] AZALIDES IMMUNOMODULATEURS DE TRIFLUOROMÉTHYL-AMINAL
  申请人：ZOETIS SERVICES LLC

  公开号：WO2021183754A1

  公开（公告）日：2021-09-16

  Defined herein are immunomodulating Formula (1) compounds, wherein R1, R2 and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.