2-Amino-3-[2,3-di(tetradecanoyloxy)propoxy-hydroxyphosphoryl]oxypropanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-Amino-3-[2,3-di(tetradecanoyloxy)propoxy-hydroxyphosphoryl]oxypropanoic acid
• 化学式: C₃₄H₆₆NO₁₀P
• 分子量: 679.9
• InChiKey: WKJDWDLHIOUPPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  46
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  172
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• Method and device for producing optimized lipid-based micro/nano-bubbles
  申请人：Trust Bio-sonics Inc.

  公开号：EP2799087B1

  公开（公告）日：2020-03-11
• SUSTAINED-RELEASE ANESTHETIC COMPOSITIONS AND METHODS OF PREPARATION THEREOF
  申请人：TLC Biopharmaceuticals, Inc.

  公开号：US20200188374A1

  公开（公告）日：2020-06-18

  Provided is an anesthetic composition for locally administrating an amide-type anesthetic into a subject in need thereof. The anesthetic composition has multilamellar vesicles with entrapped amide-type anesthetic prepared by hydrating a highly entrapped lipid structure comprising an amide-type anesthetic and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more feasible process for large-scale manufacture and for providing a high molar ratio of amide-type anesthetic to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.
• ASSAY FOR hERG CHANNEL SENSITIVITY TO SMALL MOLECULE PHARMACOLOGICAL AGENTS
  申请人：The Rockefeller University

  公开号：US20210102956A1

  公开（公告）日：2021-04-08

  The present invention provides methods and compositions relating to an assay for hERG channel protein sensitivity to small molecule pharmacological agents. In one embodiment, the invention includes an engineered hERG channel protein. In another embodiment, the invention includes a method of identifying small molecule pharmacological agents that interfere with repolarization of cardiac cells.