Fmoc-D-Dab(alloc)-OH

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-D-Dab(alloc)-OH
• 英文别名: 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(prop-2-enoxycarbonylamino)butanoic acid
• 化学式: C₂₃H₂₄N₂O₆
• 分子量: 424.4
• InChiKey: YIVBOSPUFNDYMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] DNA-TEMPLATED MACROCYCLE LIBRARY<br/>[FR] BIBLIOTHÈQUE DE MACROCYCLES À MATRICE D'ADN
  申请人：HARVARD COLLEGE

  公开号：WO2019168654A9

  公开（公告）日：2019-10-17
• DNA-TEMPLATED MACROCYCLE LIBRARY
  申请人：President and Fellows of Harvard Co

  公开号：US20200399634A1

  公开（公告）日：2020-12-24

  The present invention provides nucleic acid templates (e.g., including orthogonal codon sets (e.g., codons from orthogonal codon sets depicted in Tables 5 or 7)) for DNA-templated methods of synthesizing, selecting, and amplifying compounds (e.g., polymers and/or small molecules) described herein. Also provided are novel macrocyclic compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, libraries, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing a disease (e.g., a disease associated with aberrant enzyme activity (e.g., aberrant protease and/or kinase activity (e.g., aberrant IDE activity)), impaired insulin signaling, or insulin resistance in a subject (e.g., a subject having diabetes). Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit aberrant protease activity (e.g., aberrant IDE activity).