1-(2,3-dimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 1-(2,3-dimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• 化学式: C₁₉H₂₀N₂O₂
• 分子量: 308.4
• InChiKey: YQAZPQFCMIGDDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  46.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS
  申请人：PTC Therapeutics, Inc.

  公开号：EP3718405A1

  公开（公告）日：2020-10-07

  Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replications or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one ore more additional therapies to a human in need of such treatment.

  描述了选择性抑制人类血管内皮生长因子（VEGF）病理性生成的化合物以及包含此类化合物的组合物。描述了抑制病毒复制或病毒 RNA 或 DNA 或病毒蛋白产生的化合物以及包含此类化合物的组合物。还描述了使用此类化合物减少血管内皮生长因子的方法，以及涉及施用此类化合物的治疗癌症和非肿瘤性疾病的方法。还描述了使用此类化合物抑制病毒复制或病毒 RNA 或 DNA 或病毒蛋白产生的方法，以及施用此类化合物治疗病毒感染的方法。这些化合物可作为单剂疗法或与一种或多种额外疗法结合施用给需要治疗的人。