Isotubulosinmethylaether

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: Isotubulosinmethylaether
• 英文别名: 10,11,8'-trimethoxy-tubolosane；NZ72；8',10,11-Trimethoxytubulosan；3-ethyl-9,10-dimethoxy-2-[(6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl]-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine
• 化学式: C₃₀H₃₉N₃O₃
• 分子量: 489.658
• InChiKey: YQCYWTNBMKOEPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  58.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Methods for Sensitizing Cancer Cells to Inhibitors
  申请人：Sherman Michael

  公开号：US20090062222A1

  公开（公告）日：2009-03-05

  The present invention is based on the discovery that inactivation of the heat shock response in cancer cells significantly enhances their sensitivity to proteasome and Hsp90 inhibitors. The inventors have discovered novel compounds which exhibit low toxicity, inhibit the heat shock protein response and sensitize cancer cells to anti-cancer therapies. In general, the heat shock protein inhibitors of the present invention share a common structure, namely a 2H-benzo[a]quinolizine tricyclic ring. Also encompassed are methods for a high throughput screen to identify heat shock inhibitors that sensitize cancer cells to anti-cancer therapies.