Rhodinose | 92583-51-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: Rhodinose
• 英文别名: 2,3,6-Trideoxyhexose；6-methyloxane-2,5-diol
• CAS: 92583-51-2
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: ZCYMCBOUZXAAJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Cardiac glycoside analogs and their use in methods for inhibition of viral infection
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US10610539B2

  公开（公告）日：2020-04-07

  The present invention provides methods for inhibition of human herpes virus replication in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutically acceptable composition comprising a cardiac glycoside analog, including for example, a digitoxin analog and pharmaceutically acceptable carrier. Other methods of the present invention include administering a digitoxin analog along with at least one other biologically active compound and pharmaceutically acceptable carrier. Methods for inhibition of the α3 subtype of the Na/K ATPase in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutically acceptable composition comprising a digitoxin analog are also provided.

  本发明提供了抑制受试者体内人类疱疹病毒复制的方法，包括向受试者施用治疗有效量的药学上可接受的组合物，该组合物包含强心苷类似物，包括例如地高辛类似物和药学上可接受的载体。本发明的其他方法包括给药地高辛类似物以及至少一种其他生物活性化合物和药学上可接受的载体。本发明还提供了抑制受试者体内 Na/K ATP 酶 α3 亚型的方法，包括向受试者施用治疗有效量的包含地高辛类似物的药学上可接受的组合物。
• US7737123B2
  申请人：——

  公开号：US7737123B2

  公开（公告）日：2010-06-15
• [EN] STEROID COMPOUNDS AS ROR?t MODULATORS AND USES THEREOF<br/>[FR] COMPOSÉS STÉROÏDES COMME MODULATEURS DE ROR?T ET LEURS UTILISATIONS
  申请人：UNIV NEW YORK

  公开号：WO2012074547A2

  公开（公告）日：2012-06-07

  Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R1a, R1b, R2a, R2b, R3a, R3b, R3c, R3d, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.