2-amino-hexadecan-1,3-diol | 50731-08-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-hexadecan-1,3-diol
• 英文别名: C16 dihydrosphingosine；2-amino-1,3-hexadecanediol；D,L-2-aminohexadecane-1,3-diol；So(d16:0)；2-aminohexadecane-1,3-diol
• CAS: 50731-08-3
• 化学式: C₁₆H₃₅NO₂
• 分子量: 273.459
• InChiKey: ZKLREJQHRKUJHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-hexadecan-1,3-diol 、 三甲基氯硅烷 生成 1,3-bis(trimethylsilyloxy)hexadecan-2-amine
  参考文献：
  名称：

  HIRATA HIROHUMI; NAKASATO SATOSHI; HIGUCHI KATSUHIKO; OKIMURA MIYUKI; SHI+, YUKAGAKU, 1980, 29, NO 5, 336-340

  摘要：

  DOI：
• 作为产物：
  描述：

  肉豆蔻醛 在 palladium on activated charcoal 氢氧化钾 、 ammonium formate 作用下， 以 甲醇 为溶剂， 反应 16.0h， 生成 2-amino-hexadecan-1,3-diol
  参考文献：
  名称：

  Synthesis of sphinganine analogues modified in the head group

  摘要：

  The synthesis of sphinganine analogues modified in the head group is reported. The target compounds are efficiently prepared by means of the Henry reaction. Synthesis and results of preliminary investigations of the derivatives as potential inhibitors of sphingolipid biosynthesis are presented.

  DOI：

  10.1016/s0040-4020(01)89349-2

文献信息

• Method of making primary amide derivative
  申请人：Takasago International Corporation

  公开号：US05831125A1

  公开（公告）日：1998-11-03

  A method of selective N-acylation of an aminodiol having a primary alcoholic hydroxyl group and a secondary alcoholic hydroxyl group, in which the objective product can be prepared in high yield and without troublesome extraction and purification operations. More particularly, a method of making a primary amide derivative represented by the following general formula (3) is disclosed: ##STR1## wherein R.sup.1 represents a linear saturated aliphatic hydrocarbon group having 11 to 19 carbon atoms, R.sup.2 represents a linear saturated or unsaturated aliphatic hydrocarbon group having 9 to 19 carbon atoms which may have a hydroxyl group at the 1-position, which includes the steps of reacting an aminodiol represented by the following general formula (1): ##STR2## wherein R.sup.1 is the same as R.sup.1 in general formula (3) with a fatty acid alkyl ester represented by the following general formula (2): R.sup.2 --COO--R.sup.3 (2) wherein R.sup.2 is the same as R.sup.2 in general formula (3) and R.sup.3 represents a lower alkyl group, in a reaction system comprising an alcoholic solvent and in the presence of a basic catalyst, said reacting step forming a lower alcohol as a by-product; and removing the lower alcohol formed during the reaction from the reaction system.

  一种选择性N-酰化氨基二醇的方法，该氨基二醇具有一级醇羟基和二级醇羟基，其中目标产物可以高收率制备，无需繁琐的萃取和纯化操作。更具体地，本发明揭示了一种制备以下通式（3）所代表的主要酰胺衍生物的方法：##STR1##其中R.sup.1表示具有11至19个碳原子的线性饱和脂肪族烃基，R.sup.2表示具有9至19个碳原子的线性饱和或不饱和脂肪族烃基，该烃基可以在1位具有羟基。该方法包括以下步骤：将以下通式（1）所代表的氨基二醇与以下通式（2）所代表的脂肪酸烷基酯反应：R.sup.2--COO--R.sup.3（2）其中R.sup.2与通式（3）中的R.sup.2相同，R.sup.3表示较低的烷基，在含有醇溶剂和碱性催化剂的反应体系中进行反应，所述反应步骤形成下级醇作为副产物；并将反应过程中形成的下级醇从反应体系中除去。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT AND RELATED PRODUCTS THEREOF
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3604269A1

  公开（公告）日：2020-02-05

  The present application relates to extracting, from a traditional Chinese medicine, a plurality of compounds capable of prompting nucleic acid delivery or synthetic compounds, and promoting nucleic acid such as sRNA to absorb and enter a target cell using the extracted compounds or a plurality of combinations and promoting the nucleic acid to enter required target sites in vivo of an object.

  本申请涉及从中药中提取多种能够促使核酸递送的化合物或合成化合物，并利用提取的化合物或多种组合促进核酸（如 sRNA）吸收并进入靶细胞，并促进核酸进入物体体内所需的靶位点。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT, AND RELATED PRODUCTS
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3778556A1

  公开（公告）日：2021-02-17

  The present invention relates to extracting multiple types of compounds or synthetic compounds capable of promoting nucleic acid delivery from a traditional Chinese medicine, promoting the absorption of a nucleic acid such as sRNA and the entry thereof into a target cell by using the extracted compounds or multiple combinations, and promoting the entry of the nucleic acid into a target site in an object body having such a need. The traditional Chinese medicine is selected from traditional Chinese medicine decoction pieces derived from Rhodiola rosea, Herba Taraxaci, Herba andrographitis, and Flos Lonicerae. The nucleic acid is used for treating diseases, such as heart, spleen, kidney, stomach, lung and/or bowel diseases.

  本发明涉及从中药中提取能够促进核酸递送的多种化合物或合成化合物，利用提取的化合物或多种组合促进sRNA等核酸的吸收及其进入靶细胞，并促进核酸进入有此需要的物体体内的靶位点。所述中药选自红景天、蒲公英、穿心莲、忍冬藤等中药的煎煮片。核酸用于治疗疾病，如心、脾、肾、胃、肺和/或肠疾病。
• EXTRACTION OF PLANT SOURCE "MEDICINAL SOUP" AND MANUAL PREPARATION OF "HERBAL MEDICINE" AND RELATED PRODUCTS
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3789043A1

  公开（公告）日：2021-03-10

  Provided is a preparation method for herbal medicine, comprising the following steps: mixing one or more lipid components and/or with any one or more of the following: nucleic acid, compounds, and macromolecules; and performing heat treatment on the obtained mixture. Also provided is a method for extracting medicinal soup from plants, comprising the following steps: using a solvent to prepare extract solution of a plant; performing differential centrifugation of the extract solution; and using an aqueous solution to re-suspend the precipitate to provide the medicinal soup.

  本发明提供了一种中草药的制备方法，包括以下步骤：将一种或多种脂质成分和/或与以下任一种或多种成分混合：核酸、化合物和大分子；对得到的混合物进行热处理。还提供了一种从植物中提取药汤的方法，包括以下步骤：使用溶剂制备植物提取液；对提取液进行差速离心；以及使用水溶液重新悬浮沉淀，以提供药汤。
• A method of preparing primary amide derivatives
  申请人：Takasago International Corporation

  公开号：EP0835864B1

  公开（公告）日：2002-02-13