2-acetyl-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,4,4a,5,5a,6,11,12a-octahydrotetracene-1,11-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: 2-acetyl-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,4,4a,5,5a,6,11,12a-octahydrotetracene-1,11-dione
• 英文别名: 2-Acetyl-4-dimethylamino-4a,5a,6,12a-tetrahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-<4H,5H>-naphthacen-1,11-dion, 2-Acetyl-2-decarboxamido-tetracyclin；2-Acetyl-2-decarboxamino-tetracyclin
• 化学式: C₂₃H₂₅NO₈
• 分子量: 443.453
• InChiKey: ZPHAATWBCGBELI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.89
• 重原子数：
  32.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  155.6
• 氢给体数：
  5.0
• 氢受体数：
  9.0

文献信息

• Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds
  申请人：Cai R. Zhenhong

  公开号：US20080076738A1

  公开（公告）日：2008-03-27

  Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.

  本发明公开了至少具有一个膦酸酯基团的新型HIV整合酶抑制剂化合物、其受保护的中间体以及用于抑制HIV整合酶的方法。
• TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT
  申请人：Pommier Yves

  公开号：US20090176747A1

  公开（公告）日：2009-07-09

  The instant invention is directed towards tetracycline compositions, and methods of inhibiting Tdp1 activity, and methods of treating Tdp1-associated disorders.
• THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES
  申请人：RICCIARDI Robert P.

  公开号：US20120322770A1

  公开（公告）日：2012-12-20

  This invention provides methods of inhibiting replication of a poxvirus by contacting a poxvirus with a compound having formula I, formula XXI, formula XXXII, or formula XLI which in turn reduce, inhibit, or abrogate poxvirus DNA polymerase activity and/or its interaction with its processivity factor. Formula I, formula XXI, formula XXXII, or formula XLI can be utilized to treat humans and animals suffering from a poxvirus infection. Pharmaceutical compositions for treating poxvirus infected subjects are also provided.
• COVALENTLY FUNCTIONALIZED NANODIAMOND-BASED MALDI MATRICES AND METHODS OF USE THEREOF
  申请人：University of Saskatchewan

  公开号：US20140312218A1

  公开（公告）日：2014-10-23

  The present disclosure relates to functionalized nanodiamonds comprising at least one MALDI matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure also relates to methods of performing matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), for example on small molecules, using matrices comprising at least one MALDI matrix covalently bonded to a nanodiamond.
• US8524719B2
  申请人：——

  公开号：US8524719B2

  公开（公告）日：2013-09-03