6-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 6-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
• 化学式: C₃₁H₃₆N₂O₆
• 分子量: 532.6
• InChiKey: ZPSRBXWVBNVFTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• TOPICAL DRUG DELIVERY
  申请人：Healy Eugene Pius Joseph

  公开号：US20090298915A1

  公开（公告）日：2009-12-03

  Poly-pseudo-lysine conjugates have been shown to be able to penetrate into human skin and are proposed for both therapeutic and cosmetic treatments by topical application, e.g. change of skin pigmentation.

  聚假丝氨酸共轭物已被证明能够穿透人类皮肤，并被建议通过局部应用用于治疗和美容，例如改变皮肤色素沉着。
• Compounds, cosmetic composition and pharmaceutical composition comprising the same
  申请人：INCOSPHARM CORPORATION

  公开号：US10618874B2

  公开（公告）日：2020-04-14

  Disclosed is a novel compound, and a cosmetic composition for whitening and a pharmaceutical composition for preventing and treating a melanin hyperpigmentation disorder by activating autophagy to induce melanosome degradation and also by effectively inhibiting endocytosis of keratinocytes to interfere melanosome transfer into keratinocytes, thereby expressing an excellent effect on improvement, prevention, and treatment of a hyperpigmentation disorder induced from melanin.

  本发明公开了一种新型化合物，以及一种用于美白的化妆品组合物和一种用于预防和治疗黑色素沉着症的药物组合物，该化合物通过激活自噬诱导黑色素体降解，还通过有效抑制角质细胞的内吞作用干扰黑色素体转移到角质细胞中，从而在改善、预防和治疗由黑色素诱发的色素沉着症方面表现出卓越的效果。
• GLP-2 DERIVATIVES
  申请人：NOVO NORDISK A/S

  公开号：EP1608680A2

  公开（公告）日：2005-12-28
• PROTON CONDUCTING MEMBRANES FOR FUEL CELLS HAVING A PROTON GRADIENT AND METHODS FOR PREPARING SAID MEMBRANES
  申请人：Berthelot Thomas

  公开号：US20100304273A1

  公开（公告）日：2010-12-02

  A proton exchange membrane for a fuel cell, comprising a graft (co)polymer comprising a main chain and grafts comprising at least one proton acceptor group and at least one proton donor group.
• US7799524B2
  申请人：——

  公开号：US7799524B2

  公开（公告）日：2010-09-21