2-[2-(4-methoxyphenyl)ethyl]chromone | 92911-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-[2-(4-methoxyphenyl)ethyl]chromone
• 英文别名: 2-(4-methoxyphenethyl)-4H-chromen-4-one；2-(4-Methoxyphenethyl)chromone；2-[2-(4-methoxyphenyl)ethyl]chromen-4-one
• CAS: 92911-82-5
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.323
• InChiKey: ZQBJPQZBIGVILA-UHFFFAOYSA-N

物化性质

• 沸点：
  429.7±45.0 °C(Predicted)
• 密度：
  1.180±0.06 g/cm3(Predicted)
• 保留指数：
  2545

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(4-甲氧基苯基)丙酸 在 氢氧化钾 、 氯化亚砜 、 硫酸 作用下， 以 吡啶 、 溶剂黄146 为溶剂， 反应 1.33h， 生成 2-[2-(4-methoxyphenyl)ethyl]chromone
  参考文献：
  名称：

  Hashimoto, Keiji; Nakahara, Sachiko; Inoue, Takehisa, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 11, p. 5088 - 5091

  摘要：

  DOI：

文献信息

• [EN] 2-SUBSTITUTED-5-HYDROXY-4H-CHROMEN-4-ONES AS NOVEL LIGANDS FOR THE SEROTONIN RECEPTOR 2B (5-HT2B)<br/>[FR] 5-HYDROXY-4 H-CHROMÈNE-4-ONES SUBSTITUÉS EN 2 COMME NOUVEAUX LIGANDS POUR LE RÉCEPTEUR DE LA SÉROTONINE 2B (5-HT2B)
  申请人：UNIV VIRGINIA COMMONWEALTH

  公开号：WO2015116460A1

  公开（公告）日：2015-08-06

  A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively strong interaction with 5-HT2B compared to naturally occurring compounds (some of which are identified for the first time herein as ligands for 5-HT2B). Because the compounds, both naturally occurring and synthetically produced, function as ligands for 5-HT2B they will have application in, for example, the treatment and/or prevention of nervous system disorders such as Alzheimer's disease.

  已鉴定出一类化合物家族，其作为选择性血清素受体2B（5-HT2B）的配体。其中一些化合物是合成的非天然配体，与天然存在的化合物相比，它们与5-HT2B有相对较强的相互作用（其中一些在此处首次被确认为5-HT2B的配体）。由于这些化合物，无论是天然存在的还是合成的，都作为5-HT2B的配体，它们将在治疗和/或预防神经系统疾病如阿尔茨海默病等方面发挥作用。
• An efficient procedure for the preparation of natural products bearing the 2-(2-phenylethyl)chromone skeleton
  作者：Dwight A. Williams、Cameron Smith、Yan Zhang

  DOI：10.1016/j.tetlet.2013.06.006

  日期：2013.8

  Several 2-(2-phenylethyl)chromones have been shown to possess neuroprotective activity. However, limited synthetic methods have been disclosed to construct the 2-(2-phenylethyl)chromone skeleton. Herein, we report a straightforward 3-step preparation of five naturally occurring 2-(2-phenylethyl)chromones utilizing the Claisen condensation as the key step. Published by Elsevier Ltd.
• JPH10140179A
  申请人：——

  公开号：JPH10140179A

  公开（公告）日：1998-05-26
• 2-SUBSTITUTED-5-HYDROXY-4H-CHROMEN-4-ONES AS NOVEL LIGANDS FOR THE SEROTONIN RECEPTOR 2B (5-HT2B)
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US20170029399A1

  公开（公告）日：2017-02-02

  A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT 2B ) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively strong interaction with 5-HT2B compared to naturally occurring compounds (some of which are identified for the first time herein as ligands for 5-HT 2B ). Because the compounds, both naturally occurring and synthetically produced, function as ligands for 5-HT 2B they will have application in, for example, the treatment and/or prevention of nervous system disorders such as Alzheimer's disease.
• US9884836B2
  申请人：——

  公开号：US9884836B2

  公开（公告）日：2018-02-06