4,5,6,7-tetramethoxybenzofuran | 7168-87-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 4,5,6,7-tetramethoxybenzofuran
• 英文别名: 4,5,6,7-Tetramethoxy-1-benzofuran；4,5,6,7-tetramethoxy-1-benzofuran
• CAS: 7168-87-8
• 化学式: C₁₂H₁₄O₅
• 分子量: 238.24
• InChiKey: OKAHHQZZSODGAS-UHFFFAOYSA-N

物化性质

• 熔点：
  92.5-93.5 °C(Solv: cyclohexane (110-82-7))
• 沸点：
  131-132 °C(Press: 2 Torr)
• 密度：
  1.177±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(2-hydroxyethyl)-2,6-dimethoxyphenol 在 吡啶 、 Oxone 、 sodium methylate 、 potassium carbonate 、 sodium bromide 、 copper(I) bromide 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 生成 4,5,6,7-tetramethoxybenzofuran
  参考文献：
  名称：

  Simple and efficient synthesis of benzofuran derivatives from tyrosol

  摘要：

  A convenient strategy for the preparation of compounds bearing the benzofuran skeleton starting from tyrosol, a phenol largely present in olive oil production waste, with no biological importance, is reported. A bromination/methoxylation sequence, already described for the synthetic transformation of naturally occurring compounds, was exploited. Depending on the solvent used for the methoxylation reaction together with the presence of a 4-phenol moiety respect to the side chain, benzodihydrofurans or a benzofurans derivative can be obtained.

  DOI：

  10.1080/00397911.2015.1133828

文献信息

• Simple and efficient synthesis of benzofuran derivatives from tyrosol
  作者：Paolo Bovicelli、Fabrizio Bottaro、Carla Sappino、Michela Tomei、Valentina Nardi、Ilaria Proietti Silvestri、Beatrice Macchi、Caterina Frezza、Giuliana Righi

  DOI：10.1080/00397911.2015.1133828

  日期：2016.2

  A convenient strategy for the preparation of compounds bearing the benzofuran skeleton starting from tyrosol, a phenol largely present in olive oil production waste, with no biological importance, is reported. A bromination/methoxylation sequence, already described for the synthetic transformation of naturally occurring compounds, was exploited. Depending on the solvent used for the methoxylation reaction together with the presence of a 4-phenol moiety respect to the side chain, benzodihydrofurans or a benzofurans derivative can be obtained.