6-chloro-3-hydroxy-7-methoxyphthalide | 136203-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 6-chloro-3-hydroxy-7-methoxyphthalide
• 英文别名: 6-chloro-3-hydroxy-7-methoxy-3H-2-benzofuran-1-one
• CAS: 136203-48-0
• 化学式: C₉H₇ClO₄
• 分子量: 214.605
• InChiKey: RROMXUXWLUAFGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-chloro-3-hydroxy-7-methoxyphthalide 在 镍 氢气 、 sodium acetate 、 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Discovery of (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a Selective, Orally Active Agonist of the 5-HT_2C Receptor

  摘要：

  Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the synthesis and optimization of a new class of pyrazinoisoindolone-containing, selective 5-HT2C agonists as antiobesity agents. Key to optimization of the pyrazinoisoindolone core was the identification of the appropriate substitution pattern and functional groups which led to the discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one (58), a 5-HT2C agonist with > 300-fold functional selectivity over 5-HT2B and > 70-fold functional selectivity over 5-HT2A. Oral dosing of 58 reduced food intake in an acute rat feeding model, which could be completely reversed by a selective 5-HT2C antagonist and caused a reduction in body weight gain in a 4-day rat model.

  DOI：

  10.1021/jm0612968
• 作为产物：
  描述：

  3-chloro-2-methoxybenzoic acid chloride 在 盐酸 、 四甲基乙二胺 、 仲丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 29.5h， 生成 6-chloro-3-hydroxy-7-methoxyphthalide
  参考文献：
  名称：

  Discovery of (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a Selective, Orally Active Agonist of the 5-HT_2C Receptor

  摘要：

  Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the synthesis and optimization of a new class of pyrazinoisoindolone-containing, selective 5-HT2C agonists as antiobesity agents. Key to optimization of the pyrazinoisoindolone core was the identification of the appropriate substitution pattern and functional groups which led to the discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one (58), a 5-HT2C agonist with > 300-fold functional selectivity over 5-HT2B and > 70-fold functional selectivity over 5-HT2A. Oral dosing of 58 reduced food intake in an acute rat feeding model, which could be completely reversed by a selective 5-HT2C antagonist and caused a reduction in body weight gain in a 4-day rat model.

  DOI：

  10.1021/jm0612968

文献信息

• DBU-CH₃I, a Potential Substitute for CH₂N₂ in the Preparation of Methyl Esters and Methyl Aryl Ethers: Studies with Assorted Acids
  作者：Dipakranjan Mal、Amit Jana、Sutapa Ray、Sourav Bhattacharya、Asit Patra、Saroj R. De

  DOI：10.1080/00397910802238809

  日期：2008.10.28

  Abstract DBU-CH3I has been poised to be a substitute for diazomethane in the preparation of methyl esters from carboxylic acids. The reactions can be carried out in commercial untreated acetone and acetonitrile, which have been exemplified with several methyl esters, otherwise it is difficult to prepare. Bis-esterification using diiodomethane can also be achieved in a similar fashion. Sufficiently

  摘要 DBU-CH3I 已准备好在由羧酸制备甲酯中替代重氮甲烷。反应可以在商业未处理的丙酮和乙腈中进行，已经以几种甲酯为例，否则很难制备。使用二碘甲烷的双酯化也可以类似方式实现。足够酸性的酚也可以方便地通过该方法O-甲基化。
• Total synthesis of BE-23254, a chlorinated angucycline antibiotic
  作者：Satyajit Dey、Dipakranjan Mal

  DOI：10.1016/j.tetlet.2005.06.062

  日期：2005.8

  The first synthesis of BE-23254, an unusual angucycline antibiotic, is reported. It involves regioselective condensation of naphthalenone 4 and chlorine-containing isobenzofuranone 16 as the key step.

  据报道，BE-23254是一种罕见的安古环素抗生素的首次合成。这是关键步骤，包括萘酮4和含氯异苯并呋喃酮16的区域选择性缩合。
• Synthesis of chlorine-containing angucycline BE-23254 and its analogs
  作者：Dipakranjan Mal、Satyajit Dey

  DOI：10.1016/j.tet.2006.07.090

  日期：2006.10

  The total synthesis of BE-23254, an unusual angucycline antibiotic is reported. This is achieved by adopting a Hauser annulation and a DDQ-promoted aromatization as the key steps. The strategy has been generalized for the synthesis of several analogs of the target molecule. A regioselective preparation of chlorine-containing phenols is also described. (c) 2006 Elsevier Ltd. All rights reserved.
• Napolitano, Elio; Ramacciotti, Antonella; Morsani, Massimo, Gazzetta Chimica Italiana, 1991, vol. 121, # 5, p. 257 - 259
  作者：Napolitano, Elio、Ramacciotti, Antonella、Morsani, Massimo、Fiaschi, Rita

  DOI：——

  日期：——