A production process of an antithrombogenic and antiadhesive material for medical use
申请人:Koken Company Limited
公开号:EP0212209A1
公开(公告)日:1987-03-04
This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.
本发明涉及一种抗血栓形成和抗粘连材料的生产工艺,该材料可用作人造血管、人造瓣膜、心血管器官移植补片、人造心脏导管等。本发明的要点主要是将缩水甘油三烷基卤化铵(如缩水甘油三甲基氯化铵)与由纯胶原蛋白或胶原蛋白和其他成分(如粘多糖)组成的材料进行反应,以便在材料的胶原蛋白分子中引入阳离子季官能团,然后将肝素与引入的阳离子官能团进行离子结合。与此同时,在进行上述化学处理之前,可通过去除除胶原蛋白以外的蛋白质从狗血管中制备材料,通过粉碎成粉末从牛跟腱中制备材料,通过在蒸馏水中漂洗从人类羊膜中制备材料,或通过在聚酯针织管内涂上粉末状胶原蛋白等方法从聚酯针织管中制备材料。