NSC 39225 | 1509-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: NSC 39225
• 英文别名: 3,4-Bis--brenzcatechin；3,5-Bis--brenzkatechin；3,5-Bis-(dimethylaminomethyl)-brenzkatechin；3,5-Bis((dimethylamino)methyl)-1,2-benzenediol；3,5-bis[(dimethylamino)methyl]benzene-1,2-diol
• CAS: 1509-60-0
• 化学式: C₁₂H₂₀N₂O₂
• 分子量: 224.303
• InChiKey: GRBCQHDFWCSCPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 木榴油 、 二甲胺 生成 NSC 39225
  参考文献：
  名称：

  Reactions of Isopropyl Methylphosphonofluoridate with Substituted Phenols. II

  摘要：

  DOI：

  10.1021/ja01076a043

文献信息

• Assays for identification of topoisomerase inhibitors
  申请人：Stivers T. James

  公开号：US20080020973A1

  公开（公告）日：2008-01-24

  The instant invention provides a continuous spectroscopic assay for DNA topoisomerase activity. The invention further provides topoisomerase inhibitors and pharmaceutical compositions for the treatment of topoisomerase associated diseases and disorders.
• [EN] MDRI-INVERSE AGENTS<br/>[FR] AGENTS S'OPPOSANT AU GÈNE MDR1
  申请人：US HEALTH

  公开号：WO2010138686A1

  公开（公告）日：2010-12-02

  A method for inhibiting the growth of drug resistant cells in a subject, comprising identifying a subject having drug resistant cells; and administering to the subject a compound or a pharmaceutically acceptable salt or ester thereof, that is a MDR1 -inverse agent. Also disclosed is a method of inhibiting cancer in a subject, comprising administering to the subject an antiproliferative agent, wherein the antiproliferative effect of the agent is potentiated by P-glycoprotein and the agent is a compound, or a pharmaceutically acceptable salt or ester thereof, that is a MDR1 -inverse agent.
• Reactions of Isopropyl Methylphosphonofluoridate with Substituted Phenols. II
  作者：Joseph. Epstein、Harry O. Michel、David H. Rosenblatt、Robert E. Plapinger、Ralph A. Stephani、Edward. Cook

  DOI：10.1021/ja01076a043

  日期：1964.11