(+/-)-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-one | 103251-83-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: (+/-)-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-one
• 英文别名: 1,3,3-trimethyl-7-oxabicyclo[2.2.1]heptan-2-one；(+/-)-1,3,3-trimethyl-7-oxabicyclo[2.2.1]heptane-2-one
• CAS: 103251-83-8
• 化学式: C₉H₁₄O₂
• 分子量: 154.209
• InChiKey: JNERIEYMYUIPIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-one 在 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 N-<(o-nitrophenyl)sulfenyl>-D-phenylglycine (+/-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester
  参考文献：
  名称：

  High potency dipeptide sweeteners. 1. L-Aspartyl-D-phenylglycine esters

  摘要：

  Twenty esters of L-aspartyl-D-phenylglycine, as well as two substituted analogues, an o-fluoro and a p-hydroxy-phenylglycine ester, were prepared. The L-aspartyl-D-phenylglycine (-)-alpha- and (+)-beta-fenchyl esters had the highest sweetness potency at 1200 and 3700 times that of sucrose, respectively. The high potency of these sweeteners is surprising as the phenyl group occupies a position previously believed to accommodate only much smaller groups.

  DOI：

  10.1021/jm00165a027
• 作为产物：
  描述：

  (+/-)-1,3,3-trimethyl-2-methylene-7-oxabicyclo<2.2.1>heptane 生成 (+/-)-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-one
  参考文献：
  名称：

  JANUSZ, JOHN M.;GARDLIK, JOHN M.

  摘要：

  DOI：

文献信息

• Oxa-fenchyl amines useful for preparing high intensity sweeteners
  申请人：The Procter & Gamble Company

  公开号：US04883888A1

  公开（公告）日：1989-11-28

  Oxa-fenchols and oxa-fenchyl amines are disclosed which are useful in the preparation of high intensity sweeteners. These sweeteners can be used to sweeten a variety of foods, beverages and other oral products. The oxa-fenchols also have a pine-like fragrance which makes them potentially useful as a perfume ingredient.

  披萨-芬醇和披萨-芬基胺已被披露，可用于制备高强度甜味剂。这些甜味剂可用于调味各种食物、饮料和其他口腔产品。披萨-芬醇还具有松木般的香味，使其有可能作为香水成分。
• Oxa-fenchyl esters and amides of alpha-L-aspartyl-D-phenylglycine
  申请人：The Procter & Gamble Company

  公开号：US04677126A1

  公开（公告）日：1987-06-30

  Oxa-fenchyl esters and amides of alpha-L-aspartyl-D-phenylglycine are disclosed to be useful as high intensity sweeteners. These compounds can be used to sweeten a variety of foods, beverages and other oral products.

  氧松香脂酯和α-L-天冬氨酸-D-苯基甘氨酸的酰胺被披露为高强度甜味剂。这些化合物可用于增甜各种食品、饮料和其他口服产品。
• Alpha-L-aspartyl-D-phenylglycine esters and amides useful as high
  申请人：The Procter & Gamble Company

  公开号：US04692512A1

  公开（公告）日：1987-09-08

  alpha-L-Aspartyl-D-phenylglycine esters and amides are disclosed to be useful as high intensity sweeteners. These compounds can be used to sweeten a variety of foods, beverages and other oral products.

  alpha-L-Aspartyl-D-phenylglycine酯和酰胺被披露为高强度甜味剂。这些化合物可以用于甜化各种食品、饮料和其他口腔产品。
• Alpha-L-aspartyl-D-phenylglycine esters and amides useful as high intensity sweeteners
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0168112A2

  公开（公告）日：1986-01-15

  alpha-L-Aspartyl-D-phenylglycine esters and amides are disclosed to be useful as high intensity sweeteners. These compounds can be used to sweeten a variety of foods, beverages and other oral products.

  α-L-天冬氨酰-D-苯基甘氨酸酯和酰胺可用作高浓度甜味剂。 这些化合物可用于增加各种食品、饮料和其他口服产品的甜味。
• Oxa-fenchyl esters and amides of alpha-l-aspartyl-d-phenylglycine
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0168881A1

  公开（公告）日：1986-01-22

  Oxa-fenchyl esters and amides of alpha-L-aspartyl-D-phenylglycine are disclosed to be useful as high intensity sweeteners. These compounds can be used to sweeten a variety of foods, beverages and other oral products.

  α-L-天冬氨酰-D-苯甘氨酸的氧杂葑酯和酰胺可用作高强度甜味剂。这些化合物可用于增加各种食品、饮料和其他口服产品的甜味。