Sabadinine | 124-98-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Sabadinine
• 英文别名: (1R,2S,6S,9S,10R,11S,12S,14R,15S,18S,19S,22R,23R,25R)-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosane-1,10,11,12,14,22,23-heptol
• CAS: 124-98-1
• 化学式: C₂₇H₄₃NO₈
• 分子量: 509.6
• InChiKey: MZHXYVMEVBEFAL-GVGRLPMFSA-N

物化性质

• 熔点：
  174°C (rough estimate)
• 比旋光度：
  D17 -17.5° (aq alc)
• 沸点：
  597.1°C (rough estimate)
• 密度：
  1.1892 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  36
• 可旋转键数：
  0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  154
• 氢给体数：
  7
• 氢受体数：
  9

安全信息

• 危险等级：
  6.1(a)
• 包装等级：
  II
• 危险类别：
  6.1(a)
• 危险品运输编号：
  UN 1544

文献信息

• Chloroquine combination drugs and methods for their synthesis
  申请人：Kosak M. Kenneth

  公开号：US20070060499A1

  公开（公告）日：2007-03-15

  This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.

  这项发明揭示了氯喹偶联活性药剂的组合物，包括其制备方法。先前的技术已经表明，以足够高浓度给予氯喹作为游离药物，可以增强细胞内体内各种药剂从细胞内体释放到细胞质中。这些组合物的目的是在传递活性药剂的相同部位提供受控量的氯喹，从而减少所需的总剂量。这些组合物包括将氯喹物质直接或通过各种药用载体物质偶联到活性药剂。载体物质包括多糖、合成聚合物、蛋白质、胶束和其他用于在体内携带和释放氯喹组合物以产生治疗效果的物质。这些组合物还可以包括用于携带和释放活性药剂以用于治疗或其他医疗用途的生物可降解连接。该发明还揭示了与靶向分子偶联的载体组合物，用于将氯喹物质和活性药剂定位传递到它们的作用部位。
• Chloroquine coupled nucleic acids and methods for their synthesis
  申请人：Kosak M. Kenneth

  公开号：US20060040879A1

  公开（公告）日：2006-02-23

  This invention discloses compositions and methods for preparing chloroquine-coupled nucleic acid compositions. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the nucleic acid needs to be released, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to a nucleic acid directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing nucleic acids for therapeutic or other medical uses. The invention also discloses nucleic acid carrier compositions that are coupled to targeting molecules for targeting the delivery of nucleic acids to their site of action.

  本发明披露了制备氯喹偶联核酸组合物的组成和方法。先前的研究表明，以足够高的浓度给予氯喹作为自由药物，可以增强细胞内体内各种物质从内体泡中释放到细胞质中。这些组合物的目的是在核酸需要释放的同一位置提供受控量的氯喹，从而降低所需的总剂量。该组合物包括直接或通过各种药物载体物质偶联的氯喹物质和核酸。载体物质包括多糖、合成聚合物、蛋白质、胶束和其他用于在体内携带和释放氯喹组合物以达到治疗效果的物质。该组合物还可以包括生物可降解连接来携带和释放用于治疗或其他医疗用途的核酸。本发明还披露了偶联到靶向分子的核酸载体组合物，用于将核酸传递到其作用位置。
• TARGETING CONJUGATES COMPRISING ACTIVE AGENTS ENCAPSULATED IN CYCLODEXTRIN-CONTAINING POLYMERS
  申请人：Gnaim Jallal M.

  公开号：US20100226987A1

  公开（公告）日：2010-09-09

  A targeting conjugate is provided comprising an active agent, one or more residues of a cyclodextrin (CD)-containing polymer and a biorecognition molecule. The polymer is preferably a peptide or a polypeptide comprising at least one amino acid residue containing a functional side group to which at least one of the CD residues is linked covalently; the biorecognition molecule is covalently bonded directly or via a spacer to the polymer backbone of the CD-containing polymer; and the active agent is noncovalently encapsulated within the cavity of the cyclodextrin residues and/or entrapped within the polymer matrix of the CD-containing polymer.

  提供了一种靶向共轭物，包括活性剂、一个或多个含有环糊精（CD）的聚合物残基和生物识别分子。该聚合物最好是肽或多肽，包括至少一个氨基酸残基，其含有一个功能性侧基，至少一个CD残基与之共价连接；生物识别分子通过空间连接或直接与CD含聚合物的聚合物骨架共价键合；活性剂非共价地包装在环糊精残基的空腔内和/或被CD含聚合物的聚合物基质所包裹。
• Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
  申请人：Salus Therapeutics, Inc.

  公开号：US20030144222A1

  公开（公告）日：2003-07-31

  Amphiphilic biocompatible cyclodextrin grafted polymers comprising a hydrophobically modified cyclodextrin moiety, a linear linker and a biocompatible hydrophilic polymer backbone, wherein said cyclodextrin moiety is grafted to said biocompatible hydrophilic polymer backbone by said linker are disclosed. The cyclodextrin-grafted biocompatible polymers of this invention may be used as bioactive agent carriers. Methods of making and using such cyclodextrin-grafted biocompatible polymers are disclosed.

  本发明公开了一种含有亲水性修饰环糊精成分、线性连接剂和生物相容性亲水性聚合物骨架的两性亲合性生物相容性环糊精嫁接聚合物。其中，所述环糊精成分通过所述连接剂嫁接到所述生物相容性亲水性聚合物骨架上。本发明的环糊精嫁接生物相容性聚合物可用作生物活性剂载体。本发明还公开了制备和使用这种环糊精嫁接生物相容性聚合物的方法。
• Cockroach attraction-aggregation substance, cockroach aggregation attractant and cockroach controlling agent
  申请人：Kyoto University

  公开号：US10167269B2

  公开（公告）日：2019-01-01

  Provided is a solution for the problems associated with cockroach aggregation pheromones and cockroach aggregation attractants or cockroach controlling agents containing cockroach aggregation pheromones. In particular, provided is a compound serving as a cockroach attraction-aggregation substance, the compound being represented by general formula or a salt thereof.

  本发明提供了一种解决蟑螂聚集信息素和蟑螂聚集引诱剂或含有蟑螂聚集信息素的蟑螂控制剂相关问题的方法。特别是提供了一种用作蟑螂吸引-聚集物质的化合物，该化合物由通式或其盐表示。