(8S,9S,10R,13S,14S,17S)-17-acetyl-6-chloro-10,13-dimethyl-8,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8S,9S,10R,13S,14S,17S)-17-acetyl-6-chloro-10,13-dimethyl-8,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₁H₂₅ClO₂
• 分子量: 344.9
• InChiKey: USXVMPAWZOOYDE-HGUQNLGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• Novel antioxidants, preparation processes and their uses
  申请人：——

  公开号：US20040158092A1

  公开（公告）日：2004-08-12

  The invention concerns a process for preparing compounds of general formula (I) 1 wherein R and R′ represent an alkyl radical or an aryl group; and R″ is hydrogen or a CO—R 1 group wherein R 1 is an alkyl radical or an aryl group; and wherein these compounds are or not in the thiazolidine form; by protecting the N-acyl-L-cysteine to form an intermediate compound; and then by coupling said intermediate compound with S-acylcysteamine hydrochloride or with thiazolidine.

  这项发明涉及一种制备一般式（I）的化合物的过程 其中R和R′代表烷基基团或芳基；而R″是氢或CO—R 1 基团，其中R 1 是烷基基团或芳基；这些化合物是或不是以噻唑烷形式存在；通过保护N-酰基-L-半胱氨酸形成中间化合物；然后通过将该中间化合物与S-酰基半胱氨酸盐酸盐或噻唑烷偶联。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Amino acid derivatives
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0386611A3

  公开（公告）日：1992-04-15

  Compounds of the formula wherein R¹ represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, aroyl, cycloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyl-alkanoyl, 6-(dibenzylcarbamoyl)-4-oxohexanoyl or an acyl group of an α-amino acid in which the amino group is substituted by alkoxycaronyl, aralkoxycarbonyl, diaralkylcarbamoyl, diaralkylalkanoyl or aralkanoyl; R² represents alkyl, cycloalkylalkyl or aralkyl; R³ represents hydrogen or alkyl; R⁴ represents alkyl; and one of R⁵ and R⁶ represents hydrogen and the other represents hydrogen, alkyl, aryl, aralkyl, 1-alkoxycarbonyl-2-phenylethyl, 1-alkoxycarbonyl-2-(imidazol-4-yl)ethyl, 2-(imidazol-1-yl)ethyl, indanyl, heterocyclyl-alkyl, carboxyalkyl, alkoxycarbonylalkyl, aryloxycarbonylalkyl, aralkoxycarbonylalkyl or a group of the formula -A-N(Ra)(Rb) in which A represents alkylene and Ra and Rb each represent alkyl or Ra and Rb together represent a pentamethylene group in which one methylene group can be replaced by NH, N-alkyl, N-alkanoyl, N-aralkoxy carbonyl, O, S, SO or SO₂; or R⁵ and R⁶ together with the nitrogen atom to which they are attached represent a 1,2,3,4-tetrahydroisoquinoline ring; one of W and X represents hydrogen and the other represents hydroxy or amino or W and X together represent hydroxyimino and Y represents hydrogen or, where one of W and X represents hydrogen and the other represents hydroxy, Y can also represent hydroxy, and pharmaceutically acceptable acid addition salts thereof can be used as medicaments for the treatment and prophylaxis of viral infections, particularly of infections caused by HIV and other retroid viruses. They can be manufactured according to generally known procedures.

  该公式化合物中，其中R¹代表烷氧羰基、芳基烷氧羰基、烷酰基、芳基烷酰基、芳酰基、环烷基羰基、杂环烷基羰基、杂环烷基-烷酰基、6-(二苯甲基羰基)-4-氧代己酰基或α-氨基酸的酰基，其中氨基团被烷氧羰基、芳基烷氧羰基、二芳基甲基羰基、二芳基烷酰基或芳基取代；R²代表烷基、环烷基烷基或芳基烷基；R³代表氢或烷基；R⁴代表烷基；而R⁵和R⁶中的一个代表氢，另一个代表氢、烷基、芳基、芳基烷基、1-烷氧羰基-2-苯乙基、1-烷氧羰基-2-(咪唑-4-基)乙基、2-(咪唑-1-基)乙基、茚基、杂环烷基-烷基、羧基烷基、烷氧羰基烷基、芳氧羰基烷基、芳基烷氧羰基烷基或-A-N(Ra)(Rb)的基团，其中A代表烷基，Ra和Rb各自代表烷基，或Ra和Rb一起代表一个五甲烷基基团，其中一个亚甲基可以被NH、N-烷基、N-烷酰基、N-芳氧羰基、O、S、SO或SO₂取代；或者R⁵和R⁶与它们连接的氮原子一起代表1,2,3,4-四氢异喹啉环；W和X中的一个代表氢，另一个代表羟基或氨基，或者W和X一起代表羟亚胺基，Y代表氢或者其中一个代表氢，另一个代表羟的情况下，Y也可以代表羟，其药学上可接受的酸盐可用作治疗和预防病毒感染的药物，特别是HIV和其他逆转录病毒引起的感染。它们可以按照通常已知的程序制造。
• PROCESS FOR THE PREPARATION OF 17BETA-HYDROXY-DES-A-ANDROST-9,10-EN-5-ONE
  申请人：INDUSTRIALE CHIMICA S.R.L.

  公开号：US20180339956A1

  公开（公告）日：2018-11-29

  The present invention relates to a new process for the synthesis of 17β-hydroxy-des-A-androst-9,10-en-5-one, the compound of the following formula (1), which can be used as an intermediate in the synthesis of retroprogesterones.

  本发明涉及一种合成17β-羟基-去氢-A-雄烯-9,10-烯-5-酮的新工艺，该化合物的化学式为(1)，可用作合成反孕激素的中间体。