| 1013395-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• CAS: 1013395-44-2
• 化学式: C₃₄H₃₂N₂O₁₀
• 分子量: 628.635
• InChiKey: HAYBSYRPYGPNGL-MZBJOSPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.07
• 重原子数：
  46.0
• 可旋转键数：
  6.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  144.3
• 氢给体数：
  2.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  在 10% Pd/C 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以54%的产率得到
  参考文献：
  名称：

  Synthesis and Cytotoxic Evaluation of Some Cribrostatin–Ecteinascidin Analogues

  摘要：

  Analogues of cribrostatin IV (1) and the potent antineoplastic agent ecteinascidin 743 1 (2) have been synthesized. The cytotoxic activity of these compounds (5, 14, 20) has been determined, and the cyanoamine-cribrostatin analogue (14) exhibits a 20-fold improvement with regard to the natural product 1.

  DOI：

  10.1021/np800022x
• 作为产物：
  描述：

  在 溶剂黄146 、 锌 作用下， 反应 0.08h， 以19.9 μmol的产率得到
  参考文献：
  名称：

  Synthesis and Cytotoxic Evaluation of Some Cribrostatin–Ecteinascidin Analogues

  摘要：

  Analogues of cribrostatin IV (1) and the potent antineoplastic agent ecteinascidin 743 1 (2) have been synthesized. The cytotoxic activity of these compounds (5, 14, 20) has been determined, and the cyanoamine-cribrostatin analogue (14) exhibits a 20-fold improvement with regard to the natural product 1.

  DOI：

  10.1021/np800022x

文献信息

• Synthesis and Cytotoxic Evaluation of Some Cribrostatin–Ecteinascidin Analogues
  作者：Benjamin J. D. Wright、Collin Chan、Samuel J. Danishefsky

  DOI：10.1021/np800022x

  日期：2008.3.1

  Analogues of cribrostatin IV (1) and the potent antineoplastic agent ecteinascidin 743 1 (2) have been synthesized. The cytotoxic activity of these compounds (5, 14, 20) has been determined, and the cyanoamine-cribrostatin analogue (14) exhibits a 20-fold improvement with regard to the natural product 1.