p-2-furyl-phenol | 35461-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: p-2-furyl-phenol
• 英文别名: 4-(2-Furyl)phenol；4-(furan-2-yl)phenol
• CAS: 35461-94-0
• 化学式: C₁₀H₈O₂
• 分子量: 160.172
• InChiKey: MVKSSBPEKFRREA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-2-furyl-phenol 以33%的产率得到
  参考文献：
  名称：

  OLEJNIK A. F.; ADAMSKAYA E. V.; NOVITSKIJ K. YU.; SOLOVEVA N. P.; PERESLE+, XIMIYA GETEROTSIKL. SOEDIN., 1979, HO 1, 17-20

  摘要：

  DOI：
• 作为产物：
  描述：

  对(三甲基硅氧基)溴苯 以40%的产率得到
  参考文献：
  名称：

  KING F. D.; WALTON D. R. M., SYNTHESIS , 1976, NO 1, 40-42

  摘要：

  DOI：

文献信息

• Heterocyclic substituted-phenoxyalkylisoxazoles as antiviral useful
  申请人：Sterling Drug Inc.

  公开号：US04857539A1

  公开（公告）日：1989-08-15

  Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; Z is N or HC; R is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when Z is N, R is lower-alkyl; R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; and Het is selected from specified heterocyclic groups, are useful and antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.

  化合物的公式为##STR1##其中：Y是3-9个碳原子的烷基桥；Z是N或HC；R是氢或1-5个碳原子的低烷基，但当Z是N时，R是低烷基；R.sub.1和R.sub.2是氢、卤素、低烷基、低烷氧基、硝基、低烷氧羰基或三氟甲基；Het从指定的杂环基团中选择，对抗病毒剂，特别是对抗小RNA病毒，包括多种鼻病毒菌株。
• Metal-Free, Visible-Light-Mediated Direct C–H Arylation of Heteroarenes with Aryl Diazonium Salts
  作者：Durga Prasad Hari、Peter Schroll、Burkhard König

  DOI：10.1021/ja212099r

  日期：2012.2.15

  Visible light along with 1 mol % eosin Y catalyzes the direct C-H bond arylation of heteroarenes with aryl diazonium salts by a photoredox process. We have investigated the scope of the reaction for several aryl diazonium salts and heteroarenes. The general and easy procedure provides a transition-metal-free alternative for the formation of aryl-heteroaryl bonds.

  可见光和 1 mol% 曙红 Y 通过光氧化还原过程催化杂芳烃与芳基重氮盐的直接 CH 键芳基化。我们研究了几种芳基重氮盐和杂芳烃的反应范围。通用且简单的程序为芳基-杂芳基键的形成提供了一种不含过渡金属的替代方法。
• Hydroxy- and Aminophenyl Radicals from Arenediazonium Salts
  作者：Gerald Pratsch、Christian A. Anger、Katharina Ritter、Markus R. Heinrich

  DOI：10.1002/chem.201003713

  日期：2011.4.4

  Arenediazonium salts are well‐known sources of aryl radicals; however, the hydroxy‐ and amino‐substituted derivatives 1, 2, and 3, which lead to the respective formation of radicals 4, 5, and 6, have rarely been employed in synthetic organic chemistry so far. New synthetic applications of these species have been found, and the properties that may have previously hindered their successful use have been

  Arenediazonium盐是众所周知的芳基自由基来源。然而，羟基和氨基取代的衍生物1、2和3分别导致自由基4、5和6的形成，至今很少在合成有机化学中使用。已经发现这些物种的新的合成应用，并且已经研究了先前可能阻碍其成功使用的特性。
• An efficient protocol for the palladium-catalysed Suzuki–Miyaura cross-coupling
  作者：Alexander N. Marziale、Dominik Jantke、Stefan H. Faul、Thomas Reiner、Eberhardt Herdtweck、Jörg Eppinger

  DOI：10.1039/c0gc00522c

  日期：——

  The palladacyclic catalyst precursor received by ortho-palladation of ([1,1′-biphenyl]-2-yloxy)diisopropyl-phosphine represents a highly active system for Suzuki–Miyaura cross-coupling reactions when used in neat water. An efficient, broadly applicable and sustainable aqueous protocol was developed using 2.5 eq. of Na2CO3 as base, allowing the reaction to be performed under air and at ambient temperature with Pd loadings of 0.04 mol%. Coupling products are obtained in high yields and excellent purity by simple filtration with no organic solvents needed throughout the whole reaction. A broad variety of functional groups are tolerated and a large number of substrates can be applied with this protocol. The crystal structure of the palladacyclic catalyst precursor is presented as well as investigations targeting the nature of catalyst activation and the active catalytic species.

  通过使用无水的[1,1'-联苯]-2-基氧二异丙基膦进行邻位钯化得到的钯环状催化剂前体，在纯水体系中用于铃木-宫浦交叉偶联反应时表现出了高度活性。通过使用2.5当量的Na2CO3作为碱，我们开发了一种高效、广泛适用且可持续的水相方法，使得反应能在空气中、常温下进行，且钯的负载量仅为0.04摩尔百分比。通过简单的过滤即可获得高产率且纯度极佳的偶联产物，整个反应过程中无需任何有机溶剂。该方法对多种官能团具有耐受性，并且适用于大量不同底物。此外，本文还展示了钯环状催化剂前体的晶体结构，并探讨了催化剂活化的本质以及活性催化物种的性质。
• Plasminogen Activator Inhibitor-1 Inhibitor
  申请人：Miyata Toshio

  公开号：US20120022080A1

  公开（公告）日：2012-01-26

  The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.

  本发明提供了一种具有纤溶酶原激活物抑制剂-1抑制活性的新化合物，以及包括该化合物作为活性成分的PAI-1抑制剂。本发明还提供了一种对PAI-1活性具有抑制作用且在预防和治疗与PAI-1活性相关的各种疾病方面有效的药物组合物。