Methylpurinethiol | 1320-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Methylpurinethiol
• 英文别名: 2-methyl-7,9-dihydropurine-8-thione
• CAS: 1320-84-9
• 化学式: C₆H₆N₄S
• 分子量: 166.21
• InChiKey: QSFLEZMDDLWDPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  81.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] CELL ASSAY<br/>[FR] DOSAGE CELLULAIRE
  申请人：UNIV NEWCASTLE

  公开号：WO2016027106A1

  公开（公告）日：2016-02-25

  The invention relates to a method of measuring one or more thiopurine metabolites in a patient treated with a thiopurine drug, comprising: (i) lysing a test cell derived from said patient in a lysis buffer so as to obtain a cell lysate; and (ii) measuring one or more thiopurine metabolites in said cell lysate, wherein said lysis buffer consists of one or more reagents that do not chemically alter the phosphorylation and/or methylation state of said one or more thiopurine metabolites in said cell lysate.